Network of immune-neuroendocrine interactions.
Network of immune-neuroendocrine interactions.
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DOI：
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发表时间：
1977
影响因子：
4.6
通讯作者：
H. Besedovsky;E. Sorkin
中科院分区：
文献类型：
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作者：
H. Besedovsky;E. Sorkin
为了使自我调节的免疫系统与其他身体系统保持一致，提出了其在免疫神经内分泌网络背景下的功能。该假设基于免疫结构和神经内分泌结构之间存在传入-传出通路。主要的内分泌反应是抗原刺激的结果，并且下丘脑的电活动也会发生变化；这两种改变都与免疫反应本身暂时相关。这种内分泌反应对免疫调节和免疫特异性具有有意义的影响。在个体发育过程中，也有证据表明内分泌系统和免疫系统之间存在复杂的网络，这种双向的相互关系很可能会影响这两种功能的每个发育阶段。作为后果，免疫系统的功能和这种相互关系的结果可能对淋巴细胞稳态、自我耐受性起决定性作用，并且也可能对病理学产生重大影响。
In order to bring the self-regulated immune system into conformity with other body systems its functioning within the context of an immune-neuroendocrine network is proposed. This hypothesis is based on the existence of afferent--efferent pathways between immune and neuroendocrine structures. Major endocrine responses occur as a consequence of antigenic stimulation and changes in the electrical activity of the hypothalamus also take place; both of these alterations are temporally related to the immune response itself. This endocrine response has meaningful implications for immunoregulation and for immunospecificity. During ontogeny, there is also evidence for the operations of a complex network between the endocrine and immune system, a bidirectional interrelationship that may well affect each developmental stage of both functions. As sequels the functioning of the immune system and the outcome of this interrelation could be decisive in lymphoid cell homeostasis, self-tolerance, and could also have significant implications for pathology.