Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults
Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults
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DOI：
10.1093/gerona/glu134
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发表时间：
2015-11-01
影响因子：
5.1
通讯作者：
Newman, Anne B.
中科院分区：
文献类型：
--
作者：
Santanasto, Adam J.;Glynn, Nancy W.;Newman, Anne B.
背景随着年龄的增长，线粒体能量生产能力往往会显着下降。因此，减少线粒体功能可能有助于老年人更高水平的疲劳。方法.在30名年龄为78.5 ± 5.0岁（47%为女性，93%为白色人）的参与者中检查了疲劳性与骨骼肌线粒体功能之间的关系，他们的体重指数为25.9 ± 2.7 kg/m2，通常的步态速度为1.2 ± 0.2 m/s。以0.72 m/s的速度进行5分钟的跑步机步行后，使用感觉劳累（6-20分博格量表）评级来定义易疲劳性。使用P-31磁共振波谱测量四头肌中的磷酸肌酸恢复，并捕获四头肌的图像以计算四头肌体积。计算四头肌的ATP最大值（mM ATP/s）和氧化能力（ATP最大中心点四头肌体积）。使用改良的Balke方案测量峰值有氧能力（VO 2峰值）。结果ATPmax中心点四头肌容积与VO 2峰值相关，高强度（感觉劳累评分>= 10）组比低强度（感觉劳累评分>= 10）组低162.61 mM ATP中心点mL/s（p = 0.03
Background. Fatigability increases while the capacity for mitochondrial energy production tends to decrease significantly with age. Thus, diminished mitochondrial function may contribute to higher levels of fatigability in older adults. Methods. The relationship between fatigability and skeletal muscle mitochondrial function was examined in 30 participants aged 78.5 +/- 5.0 years ( 47% female, 93% white), with a body mass index of 25.9 +/- 2.7 kg/ m(2) and usual gait-speed of 1.2 +/- 0.2 m/s. Fatigability was defined using rating of perceived exertion ( 6-20 point Borg scale) after a 5-minute treadmill walk at 0.72 m/s. Phosphocreatine recovery in the quadriceps was measured using P-31 magnetic resonance spectroscopy and images of the quadriceps were captured to calculate quadriceps volume. ATPmax ( mM ATP/s) and oxidative capacity of the quadriceps ( ATPmax center dot Quadriceps volume) were calculated. Peak aerobic capacity ( VO2 peak) was measured using a modified Balke protocol. Results. ATPmax center dot Quadriceps volume was associated with VO2 peak and was 162.61 mM ATP center dot mL/s lower ( p =.03) in those with high ( rating of perceived exertion >= 10) versus low ( rating of perceived exertion