Gender difference in the mean age at the induction of hemodialysis in patients with autosomal dominant polycystic kidney disease
Gender difference in the mean age at the induction of hemodialysis in patients with autosomal dominant polycystic kidney disease
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DOI：
10.1016/s0272-6386(00)70042-4
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发表时间：
2000-06-01
影响因子：
13.2
通讯作者：
Kawaguchi, Y
中科院分区：
文献类型：
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作者：
Ishikawa, I;Maeda, K;Kawaguchi, Y
男性常染色体显性遗传性多囊肾病（ADPKD）患者开始血液透析早于女性患者，许多其他肾脏疾病的进展速度男性也快于女性。在本研究中，使用日本透析治疗学会年度统计调查获得的数据，比较了ADPKD与其他疾病（如慢性肾小球肾炎、糖尿病肾病和肾硬化）的性别差异。ADPKD（n = 8，176）的男女比例为1.17：1，比其他疾病更接近1.0：1。男性ADPKD患者开始血液透析治疗的时间比女性早1.3年（男性55.9 ± 12.4岁，女性57.2 ± 11.5岁），年龄差异小于其他疾病。这些结果表明，ADPKD女性患者的预后比ADPKD男性患者相对较差，或者与其他肾脏疾病相比，女性患者对这种疾病的进展没有得到很好的保护。总之，男性ADPKD患者比女性更早接受血液透析治疗;然而，与其他常见肾脏疾病相比，年龄差异较小。(C)2000年由国家肾脏基金会，公司。
Male patients with autosomal dominant polycystic kidney disease (ADPKD) begin hemodialysis earlier than female patients, The rate of progression of many other renal diseases is also faster in men than women. In this study, gender difference in ADPKD was compared with that in other diseases, such as chronic glomerulonephritis, diabetic nephropathy, and nephrosclerosis, using the data obtained from an annual statistical survey of the Japanese Society for Dialysis Therapy, The male-female ratio in ADPKD (n = 8,176) was 1.17:1 and closer to 1.0:1 than the other diseases. Men with ADPKD started hemodialysis therapy 1.3 years earlier than women (male age, 55.9 +/- 12.4 years versus female age, 57.2 +/- 11.5 years), and the age difference was less than that in other diseases. These results suggest that the prognosis in women with ADPKD is relatively worse than that in men with ADPKD or that women are not well protected against the progression of this disease compared with other renal diseases. In conclusion, men with ADPKD are introduced to hemodialysis therapy earlier than women; however, the age difference was small compared with other common renal diseases. (C) 2000 by the National Kidney Foundation, Inc.