Calcium and vitamin D intake and risk of colorectal cancer: The multiethnic cohort study
Calcium and vitamin D intake and risk of colorectal cancer: The multiethnic cohort study
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DOI：
10.1093/aje/kwk069
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发表时间：
2007-04-01
影响因子：
5
通讯作者：
Kolonel, Laurence N.
中科院分区：
文献类型：
--
作者：
Park, Song-Yi;Murphy, Suzanne P.;Kolonel, Laurence N.
多种族队列研究（夏威夷和加利福尼亚州洛杉矶）检查了钙和维生素 D 的摄入量与结直肠癌风险的关联。 1993-1996年，年龄≥45岁的85,903名男性和105,108名女性完成了定量食物频率调查问卷。截至 2001 年 12 月 31 日，共发现了 2,110 例结直肠癌病例（男性 1,138 例，女性 972 例）。使用 Cox 比例风险模型计算多变量调整后的相对风险和 95% 置信区间。对于男性（最高五分位数与最低五分位数：相对风险 (RR) = 0.70，95% 置信区间 (CI)：0.52, 0.93；p 趋势 = 0.006）和女性（RR = 0.64，95% CI：0.50, 0.83；p 趋势 = 0.003）。男性维生素 D 摄入总量也存在负相关（RR = 0.72，95% CI：0.51，1.00；趋势 p = 0.03），但女性则不然。乳制品的摄入量与结直肠癌风险呈负相关，尤其是在不补充钙的情况下（男性：RR = 0.77，95% CI：0.59，1.01；女性：RR = 0.66，95% CI：0.49，0.89）。研究结果支持了钙、维生素 D 和乳制品对结直肠癌风险具有保护作用的假设。
The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged >= 45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of colorectal cancer (1,138 in men and 972 in women) were identified through December 31, 2001. Cox proportional hazards models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals. Total calcium intake (from foods and supplements) was inversely associated with colorectal cancer risk in both men (highest quintile vs. lowest: relative risk (RR) = 0.70, 95% confidence interval (CI): 0.52, 0.93; p for trend = 0.006) and women (RR = 0.64, 95% CI: 0.50, 0.83; p for trend = 0.003). The inverse association was also seen for total vitamin D intake in men (RR = 0.72, 95% CI: 0.51, 1.00; p for trend = 0.03) but not in women. Intake of dairy products was inversely associated with colorectal cancer risk, especially among nonusers of supplemental calcium (men: RR = 0.77, 95% CI: 0.59, 1.01; women: RR = 0.66, 95% CI: 0.49, 0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer.