Perinatal ‘programming’ of insulin resistance in childhood: critical impact of neonatal insulin and low birth weight in a risk population
Perinatal ‘programming’ of insulin resistance in childhood: critical impact of neonatal insulin and low birth weight in a risk population
复制标题
儿童期胰岛素抵抗的围产期“编程”：新生儿胰岛素和低出生体重对高危人群的关键影响
作者：
T. Harder;R. Kohlhoff;G. Dörner;W. Rohde;A. Plagemann
目的低出生体重儿可能是日后胰岛素抵抗和高胰岛素血症的易感因素，但其病理生理机制尚不清楚。 围产期内分泌状况可能起重要作用，但研究较少。母亲在怀孕期间患有糖尿病的儿童是日后胰岛素抵抗和高胰岛素血症的重要风险人群。因此，我们研究了这些儿童的出生体重、出生时胰岛素和胰岛素抵抗以及婴儿期胰岛素分泌和胰岛素抵抗之间的关系。
Aim Low birth weight may predispose to later insulin resistance and hyperinsulinaemia, but the pathophysiological mechanisms are unclear. The perinatal endocrine situation may play an important role, but has been little studied. Children of mothers with diabetes during pregnancy are an important risk population for later insulin resistance and hyperinsulinaemia. We therefore examined relationships between birth weight, insulin and insulin resistance at birth, and insulin secretion and insulin resistance in infancy in these children.
DOI：
10.1210/jcem.83.8.5054
发表时间：
1998-08
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
R. Legro;D. Finegood;A. Dunaif
通讯作者：
R. Legro;D. Finegood;A. Dunaif