Circulating Concentrations of Monocyte Chemoattractant Protein-1, Plasminogen Activator Inhibitor-1, and Soluble Leukocyte Adhesion Molecule-1 in Overweight/Obese Men and Women Consuming Fructose-or Glucose-Sweetened Beverages for 10 Weeks
Circulating Concentrations of Monocyte Chemoattractant Protein-1, Plasminogen Activator Inhibitor-1, and Soluble Leukocyte Adhesion Molecule-1 in Overweight/Obese Men and Women Consuming Fructose-or Glucose-Sweetened Beverages for 10 Weeks
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DOI：
10.1210/jc.2011-1050
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发表时间：
2011-12-01
影响因子：
5.8
通讯作者：
Havel, Peter J.
中科院分区：
文献类型：
--
作者：
Cox, Chad L.;Stanhope, Kimber L.;Havel, Peter J.
背景：动物研究的结果表明，摄入大量果糖会促进炎症并损害纤维蛋白溶解。目前还没有关于果糖摄入量对人类促炎和促血栓标记物循环水平影响的数据。目的：我们的目的是确定10周的饮食果糖或葡萄糖消耗对血浆单核细胞趋化蛋白-1（MCP-1）、纤溶酶原激活物抑制剂-1（派-1）、E-选择素、细胞间粘附分子-1、C-反应蛋白、设计和设置：这是一项平行组研究，包括两个住院期（2周基线，最后2周干预），在临床研究机构中进行，和门诊期（8周），在此期间受试者住在家里。参与者年龄较大（40-72岁），超重/肥胖（体重指数= 25-35 kg/m2）男性（n = 16）和女性（n = 15）。参与者饮用葡萄糖或果糖甜饮料，提供10周能量需求的25%。主要观察指标：摄入果糖组MCP-1（P = 0.009）、派-1（P = 0.002）、E-选择素（P = 0.048）和餐后派-1（P < 0.0001）水平均高于摄入葡萄糖组。空腹C-反应蛋白、IL-6和细胞间粘附分子-1水平在两组中均无变化。结论：摄入果糖10周可导致MCP-1、派-1和E-选择素水平升高。这些发现表明果糖可能通过影响促炎和促血栓介质而促进代谢综合征的发展。（临床内分泌代谢杂志96：E2034-E2038，2011）
Context: Results from animal studies suggest that consumption of large amounts of fructose can promote inflammation and impair fibrinolysis. Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable.Objective: Our objective was to determine the effects of 10 wk of dietary fructose or glucose consumption on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), E-selectin, intercellular adhesion molecule-1, C-reactive protein, and IL-6.Design and Setting: This was a parallel-arm study with two inpatient phases (2 wk baseline, final 2 wk intervention), conducted in a clinical research facility, and an outpatient phase (8 wk) during which subjects resided at home.Participants: Participants were older (40-72 yr), overweight/obese (body mass index = 25-35 kg/m(2)) men (n = 16) and women (n = 15).Interventions: Participants consumed glucose-or fructose-sweetened beverages providing 25% of energy requirements for 10 wk. Blood samples were collected at baseline and during the 10th week of intervention.Main Outcome Measures: Fasting concentrations of MCP-1 (P = 0.009), PAI-1 (P = 0.002), and E-selectin (P = 0.048) as well as postprandial concentrations of PAI-1 (P < 0.0001) increased in subjects consuming fructose but not in those consuming glucose. Fasting levels of C-reactive protein, IL-6, and intercellular adhesion molecule-1 were not changed in either group.Conclusions: Consumptionoffructose for 10 wk leads to increases of MCP-1, PAI-1, and E-selectin. These findings suggest the possibility that fructose may contribute to the development of the metabolic syndrome via effects on proinflammatory and prothrombotic mediators. (J Clin Endocrinol Metab 96: E2034-E2038, 2011)