TYPE-II ESTROGEN-RECEPTORS IN THE PAPILLARY CYSTIC TUMOR OF THE PANCREAS
TYPE-II ESTROGEN-RECEPTORS IN THE PAPILLARY CYSTIC TUMOR OF THE PANCREAS
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DOI：
10.1093/ajcp/92.5.572
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发表时间：
1989-11-01
影响因子：
3.5
通讯作者：
CAPELLI, A
中科院分区：
文献类型：
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作者：
CARBONE, A;RANELLETTI, FO;CAPELLI, A
本文报告两例胰腺乳头状囊性肿瘤（PTC）雌激素受体（ER）和孕激素受体（PgRs）的表达。PCT和正常胰腺都能够特异性结合3 H-雌二醇。这种结合几乎完全是由于存在高水平的II型ER，而I型ER不存在或存在于非常低的水平。对正常胰腺和肿瘤胰腺细胞核ER的化学研究均为阴性。 这可以解释为假设抗ER抗体对I型结合位点具有特异性。总之，特异性雌激素和孕激素结合的存在可以解释PCT的性别和年龄偏好，并提示该肿瘤可能对激素敏感。
Two cases of papillary cystic tumor (PTC) of the pancreas were investigated for the presence of estrogen receptors (ERs) and progesterone receptors (PgRs). Both PCT and normal pancreas are able to specifically bind 3H-estradiol. This binding almost exclusively results from the presence of high levels of type II ER, whereas type I ERs were absent or present at very low levels. Both normal and neoplastic pancreas studied immunohistochemically for the presence of nuclear ER had negative results. This could be explained assuming that anti-ER antibodies are specific for type I binding sites. In conclusion, the presence of specific estrogen as well as progesterone binding may explain the sex and age predilection of PCT and suggest a possible hormone sensitivity for this tumor.