CORTICAL NEURONAL MECHANISMS IN FLUTTER-VIBRATION STUDIED IN UNANESTHETIZED MONKEYS . NEURONAL PERIODICITY AND FREQUENCY DISCRIMINATION
CORTICAL NEURONAL MECHANISMS IN FLUTTER-VIBRATION STUDIED IN UNANESTHETIZED MONKEYS . NEURONAL PERIODICITY AND FREQUENCY DISCRIMINATION
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DOI：
10.1152/jn.1969.32.3.452
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发表时间：
1969-01-01
影响因子：
2.5
通讯作者：
HYVARINEN, J
中科院分区：
文献类型：
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作者：
MOUNTCASTLE, VB;TALBOT, WH;HYVARINEN, J
本研究是该研究计划的一部分，其目的是了解躯体感觉的神经机制，后者考虑了时间、强度和空间域中的刺激-反应关系。早期的研究表明，一种具有启发性和解释性价值的方法是直接比较人类在处理某些刺激模式时的表现-在检测，识别，辨别和缩放-与猴子躯体传入系统中由这些相同刺激引起的神经事件（18）。例如，在一项关于颤振感觉的研究中，就做了这一点（32）。振荡机械刺激被传递到人类受试者的手的无毛皮肤，并且在人类敏感的频率范围内建立阈值检测功能。将完全相似的刺激传递到猴子手部的无毛皮肤上，同时记录它们在支配手部的大型有髓传入神经中诱发的一连串脉冲的电信号。结果发现，相关的一阶信号，在强度水平匹配人类的检测阈值，是一阶神经纤维中的脉冲的周期性有序列车的外观。证据进一步表明，颤振是一种双重感觉，由两组完全不同的外周纤维提供服务。终止于无毛皮肤脊部的大的、有髓鞘的、快速适应的纤维提供
THE AIM of the program of research of which the present work is a part is to understand the neural mechanisms in somatic sensation, the latter considered in terms of the stimulus-response relations in the temporal as well as in the intensive and spatial domains. Earlier studies have shown that an approach of some heuristic and explanatory value is to compare directly measures of the human performance when dealing with certain patterns of stimuli-in detection, recognition, discrimination, and scaling-with the neural events elicited by those same stimuli in the somatic afferent system of monkeys (18). This was done, for example, in a study of the sense of fluttervibration(32). Oscillating mechanical stimuli were delivered to the glabrous skin of the hands of human subjects, and the threshold detection function established over the range of frequencies to which humans are sensitive. Exactly similar stimuli were delivered to the glabrous skin of monkeys’ hands while recording the electrical signs of the trains of impulses evoked by them in the large myelinated afferents innervating the hand. It was found that the relevant first-order signal, at intensity levels matching human detection thresholds, is the appearance of periodically ordered trains of impulses in first-order nerve fibers. The evidence suggested further that flutter-vibration is properly a dual sense, served by two quite distinct sets of peripheral fibers. The large, myelinated, quickly adapting fibers which terminate in the ridges of the glabrous skin provide