QUANTITATIVE MUSCLE ULTRASOUND VERSUS QUANTITATIVE MAGNETIC RESONANCE IMAGING IN FACIOSCAPULOHUMERAL DYSTROPHY
QUANTITATIVE MUSCLE ULTRASOUND VERSUS QUANTITATIVE MAGNETIC RESONANCE IMAGING IN FACIOSCAPULOHUMERAL DYSTROPHY
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DOI：
10.1002/mus.24247
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发表时间：
2014-12-01
期刊：
影响因子：
3.4
通讯作者：
van Alfen, Nens
中科院分区：
文献类型：
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作者：
Janssen, Barbara H.;Pillen, Sigrid;van Alfen, Nens
引言：超声和磁共振成像（MRI）是非侵入性方法，可以重复进行，没有不适。在神经肌肉疾病的评估中，尚不清楚它们是否提供了补充信息。在这项研究中，我们测试了面肩肱型肌营养不良症（FSHD）患者。方法：我们对5例FSHD患者进行了腿部定量肌肉超声（QMUS）和定量MRI（QMRI）检查。结果：QMUS确定的Z分数与QMRI确定的肌肉分数和T1信号强度（SI）之间的相关性非常高。QMUS具有比QMRI更宽的动态范围，而QMRI可以检测肌肉长度上的病理不均匀分布。结论：QMUS和QMRI均适用于肌营养不良症的成像。QMUS更宽的动态范围在晚期疾病阶段的随访中可能是有利的，而QMRI似乎更适合于影响深层肌肉层并显示不均匀异常分布的FSHD等病理。肌肉神经50：968-975，2014
Introduction: Ultrasound and magnetic resonance imaging (MRI) are non-invasive methods that can be performed repeatedly and without discomfort. In the assessment of neuromuscular disorders it is unknown if they provide complementary information. In this study we tested this for patients with facioscapulohumeral muscular dystrophy (FSHD). Methods: We performed quantitative muscle ultrasound (QMUS) and quantitative MRI (QMRI) of the legs in 5 men with FSHD. Results: The correlation between QMUS-determined z-scores and QMRI-determined muscle fraction and T1 signal intensity (SI) was very high. QMUS had a wider dynamic range than QMRI, whereas QMRI could detect inhomogeneous distribution of pathology over the length of the muscles. Conclusions: Both QMUS and QMRI are well suited for imaging muscular dystrophy. The wider dynamic range of QMUS can be advantageous in the follow-up of advanced disease stages, whereas QMRI seems preferable in pathologies such as FSHD that affect deep muscle layers and show inhomogeneous abnormality distributions. Muscle Nerve 50: 968-975, 2014