Thymus dependence of rabies vaccine.
Thymus dependence of rabies vaccine.
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狂犬病疫苗的胸腺依赖性。
DOI：
10.1099/0022-1317-33-3-535
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
G. Turner
中科院分区：
文献类型：
--
作者：
G. Turner
在裸鼠及其正常同窝小鼠中，比较了狂犬病疫苗与已知胸腺依赖性和胸腺非依赖性抗原的免疫应答。在接种1或2剂狂犬病疫苗的裸鼠中未观察到对攻击的抗体应答或保护。单剂量相同的疫苗诱导了大量的抗体反应，并保护了正常小鼠。提示狂犬病疫苗中诱导中和抗体和保护小鼠的抗原是胸腺依赖性的。
Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.