Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea.
Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea.
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DOI：
10.3346/jkms.2020.35.e391
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发表时间：
2020-11-09
影响因子：
4.5
通讯作者：
Sol IS
中科院分区：
文献类型：
--
作者：
Kim H;Shim JY;Ko JH;Yang A;Shim JW;Kim DS;Jung HL;Kwak JH;Sol IS
自2020年4月中旬以来，欧洲和北美报告了与2019年类似川崎病(KD)的冠状病毒病相关的儿童多系统炎症综合征(MIS-C)病例。然而，韩国还没有病例报告。我们描述了一名11岁的男孩，他在重症监护病房出现了需要肌松药的低血压，并伴有发热、腹痛和腹泻。他的血液测试显示炎症标志物升高，血小板减少，低蛋白血症和凝血障碍。之后，他出现了KD的症状，如结膜注射、草莓状舌头、嘴唇破裂、冠状动脉扩张，以及没有呼吸道症状的实质实变。微生物检测均为阴性，包括严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)逆转录聚合酶链式反应。而血清抗SARS-CoV-2免疫球蛋白G经酶联免疫吸附试验和荧光免疫试验重复试验均为阳性。他在静脉注射免疫球蛋白后恢复良好，于入院第13天出院，无并发症。我们报告首例符合不完全KD或KD休克综合征特征的韩国儿童。
Since mid-April 2020, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 that mimics Kawasaki disease (KD) have been reported in Europe and North America. However, no cases have been reported in Korea. We describe an 11-year old boy with fever, abdominal pain, and diarrhea who developed hypotension requiring inotropes in intensive care unit. His blood test revealed elevated inflammatory markers, thrombocytopenia, hypoalbuminemia, and coagulopathy. Afterward, he developed signs of KD such as conjunctival injection, strawberry tongue, cracked lip, and coronary artery dilatation, and parenchymal consolidation without respiratory symptoms. Microbiological tests were all negative including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction. However, serum immunoglobulin G against SARS-CoV-2 was positive in repeated tests using enzyme-linked immunosorbent assay and fluorescent immunoassay. He was recovered well after intravenous immunoglobulin administration and discharged without complication on hospital day 13. We report the first Korean child who met all the criteria of MIS-C with features of incomplete KD or KD shock syndrome.
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影响因子：
4.5
作者：
Lee, Jin;Kim, Ki Hwan;Kim, Jong-Hyun
通讯作者：
Kim, Jong-Hyun
影响因子：
8
作者：
Liu, Li;Wei, Qiang;Chen, Zhiwei
通讯作者：
Chen, Zhiwei
DOI：
10.1136/bmj.m2094
发表时间：
2020-06-03
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Toubiana J;Poirault C;Corsia A;Bajolle F;Fourgeaud J;Angoulvant F;Debray A;Basmaci R;Salvador E;Biscardi S;Frange P;Chalumeau M;Casanova JL;Cohen JF;Allali S
通讯作者：
Allali S
影响因子：
1.6
作者：
Ma, Le;Zhang, Ya-Yuan;Yu, Hai-Guo
通讯作者：
Yu, Hai-Guo
影响因子：
158.5
作者：
Dufort, Elizabeth M.;Koumans, Emilia H.;Zucker, Howard
通讯作者：
Zucker, Howard