The association between gout and cataract risk: A meta-analysis
The association between gout and cataract risk: A meta-analysis
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DOI：
10.1371/journal.pone.0180188
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发表时间：
2017-06-29
期刊：
影响因子：
3.7
通讯作者：
Yao, Ke
中科院分区：
文献类型：
--
作者：
Luo, Chenqi;Chen, Xinyi;Yao, Ke
PurposeTo evaluate the relationship between gout and age-related cataracts（ARCs）.MethodsA comprehensive literature search of the PubMed and Web of Science databases was carried out to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017.计算合并相对风险（RR）或比值比（OR）及其相应的95%置信区间（CI）。结果共纳入3项横断面研究和3项病例对照研究，其中1项为随机效应模型，另1项为固定效应模型。痛风与ARC发生率增加显著相关（OR 1.53，95%CI 1.27-1.84）。在亚组分析中，痛风与后囊下白内障（PSC，OR 1.69，95% CI：1.06-2.70）和皮质性白内障（CC，OR 1.39，95% CI：1.06-1.81）的几率呈正相关。然而，痛风和核性白内障的几率之间没有关联被确定。ConclusionsThe目前的文献表明，痛风可能与ARC的几率增加，特别是PSC和CC。应进一步努力证实这些发现，并澄清痛风和痛风药物对白内障发展的影响。
PurposeTo evaluate the relationship between gout and age-related cataracts (ARCs).MethodsA comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The random-effects model was used instead of the fixed-effects model when heterogeneity was identified, as indicated by a Cochran's Q statistic P-value 50%.ResultsA total of 3 cross-sectional studies and 3 case-control studies were included in the meta-analysis. Gout was significantly associated with increased odds of ARCs (OR 1.53, 95% CI 1.27-1.84). In the subgroup analysis, gout exhibited positive associations with the odds of posterior subcapsular cataracts (PSCs, OR 1.69, 95% CI: 1.06-2.70) and cortical cataracts (CCs, OR 1.39, 95% CI: 1.06-1.81). However, no association was identified between gout and the odds of nuclear cataracts.ConclusionsThe current literature suggested that gout may be associated with increased odds of ARCs, especially PSCs and CCs. Further efforts should be made to confirm these findings and clarify the effect of gout and gout medications on the development of cataracts.