Cellular Distribution and Expression of Cortical Acetylcholine Receptors in Aging and Alzheimer's Disease a
Cellular Distribution and Expression of Cortical Acetylcholine Receptors in Aging and Alzheimer's Disease a
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衰老和阿尔茨海默病中皮质乙酰胆碱受体的细胞分布和表达
DOI：
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发表时间：
1991
影响因子：
5.2
通讯作者：
A. Strosberg
中科院分区：
文献类型：
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作者：
H. Schröder;E. Giacobini;R. Struble;K. Zilles;A. Maelicke;P. Luiten;A. Strosberg
配基结合研究表明，在阿尔茨海默病中，尼古丁结合位点显著减少，但毒扁豆碱结合位点没有明显减少。我们用单抗免疫组织化学方法研究了中年对照组(55+/-5岁)、年龄匹配对照组(73+/-6岁)和阿尔茨海默病患者(74+/-5岁)额叶皮质中各自受体蛋白的表达。中年对照组烟碱能胆碱能神经元密度为8000个/mm~3，年龄匹配对照组为4000个/mm~3，而阿尔茨海默病组仅为900个/mm~3(p<0.0001)。M胆碱胆碱能神经元和尼氏染色神经元的密度在两组之间没有显著差异，这表明随着年龄的增长和阿尔茨海默病患者皮质神经元中尼古丁受体蛋白的表达选择性下降。
Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding sites in Alzheimer's disease. Using monoclonal antibodies we studied immunohistochemically the expression of the respective receptor proteins in the frontal cortex of middle-aged (55 +/- 5 yr) controls, age-matched controls (73 +/- 6 yr), and patients with Alzheimer's disease (74 +/- 5 yr). Density of nicotinic cholinoceptive neurons was 8000/mm3 for middle-aged controls and 4000/mm3 for age-matched controls, but only 900/mm3 in Alzheimer's brains (p less than 0.0001). Densities of muscarinic cholinoceptive and of Nissl-stained neurons were not significantly different between the groups, pointing to a selective decrease of nicotinic receptor protein expression in cortical neurons with aging and in Alzheimer's disease.
人脑胆碱能受体系统：衰老和阿尔茨海默病的神经化学和药理学方面。
影响因子：
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作者：
Giacobini,E;DeSarno,P;Clark,B;McIlhany,M
通讯作者：
McIlhany,M