MUTAGENICITY OF METHYLATED FLUORENES AND BENZOFLUORENES
MUTAGENICITY OF METHYLATED FLUORENES AND BENZOFLUORENES
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DOI：
10.1016/0165-7992(81)90027-0
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
HOFFMANN, D
中科院分区：
文献类型：
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作者：
LAVOIE, EJ;TULLEY, L;HOFFMANN, D
测定了甲基化芴[1-甲基芴、2-甲基芴、3-甲基芴、4-甲基芴、9-甲基芴、1，9-二甲基芴、2，3-二甲基芴、9，9-二甲基芴、1，1-二苯基乙烷、9-羟甲基芴、9-甲基-9-芴醇和9-氢过氧-9-甲基芴]对鼠伤寒沙门氏菌TA 98和TA 100的致突变活性。在不存在代谢活化的情况下，这些甲基芴均无致突变性。在9000 ×Aroclor诱导的大鼠上清液中，9-甲基芴和1，9-二甲基芴对TA 98和TA 100具有活性。该系列中致突变活性的结构要求是在9位存在单个甲基取代基。在苯甲基位置类似甲基化的苯并芴[苯并（a）芴、苯并（B）芴、苯并（c）芴、11-甲基苯并（a）芴、11-甲基苯并（B）芴和7-甲基苯并（c）芴]也观察到增强的致突变活性。
Methylated fluorenes [1-methylfluorene, 2-methylfluorene, 3-methylfluorene, 4-methylfluorene, 9-methylfluorene, 1,9-dimethylfluorene, 2,3-dimethylfluorene, 9,9-dimethylfluorene, 1,1-diphenylethane, 9-hydroxymethylfluorene, 9-methyl-9-fluorenol and 9-hydroperoxy-9-methylfluorene] were assayed for mutagenic activity towards Salmonella typhimurium TA98 and TA100. None of these methylfluorenes were mutagenic in the absence of metabolic activation. In the presence of 9000 .times. g supernatant from Aroclor-induced rats, 9-methylfluorene and 1,9-dimethylfluorene were active towards TA98 and TA100. The structural requirement for mutagenic activity within this series was the presence of a single methyl substitutent at the 9-position. Enhanced mutagenic activity was also observed for benzofluorenes [benzo(a)fluorene, benzo(b)fluorene, benzo(c)fluorene, 11-methylbenzo(a)fluorene, 11-methylbenzo(b)fluorene and 7-methylbenzo(c)fluorene] similarly methylated at their benzylic positions.