XThe role of cystatin C and the angiogenic cytokines VEGF and bFGF in patients with esophageal carcinoma
XThe role of cystatin C and the angiogenic cytokines VEGF and bFGF in patients with esophageal carcinoma
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DOI：
10.1385/mo:22:1:029
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发表时间：
2005-01-01
期刊：
影响因子：
3.4
通讯作者：
Bergqvist, M
中科院分区：
文献类型：
--
作者：
Dreilich, M;Wagenius, G;Bergqvist, M
血管生成是从现有血管床中形成新血管。血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）是有效的循环血管生成因子，而胱抑素C是几种半胱氨酸蛋白酶的最重要的细胞外抑制剂之一。由于蛋白酶在肿瘤生长和转移过程中降解间质结缔组织和基底膜，胱抑素C和血管生成因子之间的关联似乎是合理的。本研究的主要目的是调查这些血清标志物之间是否存在这种相关性。第二个目的是确定治疗前收集的这些循环细胞因子和胱抑素C对食管癌患者的预后价值。共有42例食管癌患者在治疗前捐献血清样本。VEGF和bFGF与血小板和白细胞计数相关，VEGF与肿瘤体积相关（p = 0.04），而bFGF则不相关（p = 0.08）。VEGF与胱抑素C显著相关（p = 0.027）。生存分析显示，VEGF作为一个连续变量，在单变量分析中与显著较差的生存相关（p = 0.023）;然而，bFGF没有发现这一点（p = 0.46）。在多变量分析中，两种血管生成因素均与生存率无关。在单因素分析中，胱抑素C与生存率相关（p = 0.01），但在多因素分析中没有发现（p = 0.28）。总之，VEGF与胱抑素C相关，可能的解释在本文中进行了讨论。本研究的结果表明，使用血管生成因子作为预后因素，在食管癌患者治疗前，似乎是有限的。
Angiogenesis is the formation of new blood vessels out of the existing vascular bed. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are potent circulating angiogenic factors, whereas cystatin C is one of the most important extracellular inhibitors of several cysteine proteinases. Because proteases degrade interstitial connective tissue and basement membranes during tumor growth and metastasis, an association between cystatin C and the angiogenic factors seems plausible. The primary aim of the present study was to investigate if such a correlation exists between these serum markers. The secondary aim was to determine the prognostic value of these circulating cytokines and cystatin C, collected prior to therapy, in patients with esophageal carcinoma.A total of 42 patients with esophageal carcinoma donated serum samples prior to therapy. VEGF and bFGF were correlated to platelet and leukocyte counts and VEGF was correlated to tumor volume (p = 0.04), whereas bFGF was not (p = 0.08). VEGF was significantly correlated with cystatin C (p = 0.027). Survival analysis showed that VEGF regarded as a continuous variable was associated with a significantly poorer survival in the univariate analysis (p = 0.023); however, this was not found for bFGF (p = 0.46). Neither of the angiogenic factors were associated with survival in the multivariate analysis. In the univariate analysis, cystatin c was correlated with survival (p = 0.01), but this was not found in the multivariate analysis (p = 0.28).In conclusion, VEGF was correlated with cystatin C, possible explanations being discussed in the present article. Results of the present study indicate that use of the angiogenic factors as prognostic factors, prior to therapy in patients with esophageal carcinoma, appears limited.