Atypical Protein Kinase C λ/ι Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma
Atypical Protein Kinase C λ/ι Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma
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DOI：
10.21873/anticanres.12985
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发表时间：
2018-11-01
影响因子：
2
通讯作者：
Tohnai, Iwai
中科院分区：
文献类型：
--
作者：
Baba, Junichi;Kioi, Mitomu;Tohnai, Iwai
背景/目的：非典型蛋白激酶C λ/i ota（aPKC λ/i ota）是位于上皮细胞的紧密连接和顶膜中的细胞极性调节剂。先前的研究表明，aPKC λ/iota过表达和异常定位参与了几种癌症的肿瘤进展。我们研究了aPKC λ/iota与口腔鳞状细胞癌（OSCC）的关系。材料与方法：应用免疫组化方法检测76例口腔鳞癌组织中aPKC λ/iota表达与临床病理参数的关系。结果：36.8%的病例中观察到aPKC λ/iota过表达。aPKC λ/iota表达在低分化口腔鳞癌和年轻患者中更强（
Background/Aim: Atypical protein kinase C lambda/iota (aPKC lambda/iota) is a cell polarity-regulator localized in the tight junction and apical membrane in epithelial cells. Previous studies suggested that aPKC lambda/iota overexpression and abnormal localization were involved in tumor progression in several cancers. We investigated the relationship between aPKC lambda/iota and oral squamous cell carcinoma (OSCC). Materials and Methods: The correlation between the aPKC lambda/iota expression and the clinicopathological parameters in 76 OSCC cases was examined using immunohistochemical analyses. Results: aPKC lambda/iota overexpression was observed in 36.8% of cases. aPKC lambda/iota expression was more intense in poorly differentiated OSCC and younger patients (