Nutshell Extracts of Xanthoceras sorbifolia: A New Potential Source of Bioactive Phenolic Compounds as a Natural Antioxidant and Immunomodulator
Nutshell Extracts of Xanthoceras sorbifolia: A New Potential Source of Bioactive Phenolic Compounds as a Natural Antioxidant and Immunomodulator
复制标题
文冠果壳提取物：作为天然抗氧化剂和免疫调节剂的生物活性酚类化合物的新潜在来源
DOI：
10.1021/acs.jafc.7b05590
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发表时间：
2018
影响因子：
6.1
通讯作者：
Zhang Yuan
中科院分区：
文献类型：
--
作者：
Zhao Li;Li Xing;Ye Ze-Qing;Zhang Fei;Han Juan-Juan;Yang Ting;Wang Zhe-Zhi;Zhang Yuan
文冠果的坚果壳是食用油生产中的一种废弃物，富含对健康有益的酚酸。然而，其单个成分、生物活性和作用机制在很大程度上尚不清楚。本研究对黄毛菊坚果壳提取物中的20种酚类化合物进行了结构鉴定。气相色谱-质谱联用技术分析文冠果中的黄酮类化合物。四项已建立的体外研究表明，NE具有显着的抗氧化潜力。体内实验结果表明，口服NE可有效减轻实验性自身免疫性脑脊髓炎（EAE）的临床病情，减轻神经炎症和中枢神经系统（CNS）脱髓鞘。NE诱导效应的潜在机制涉及减少病原性免疫细胞进入CNS的渗透，减少促炎细胞因子和因子的产生，并通过Janus激酶/信号转导子和转录激活子途径抑制1型T辅助细胞和17型T辅助细胞的分化。综上所述，我们的研究表明，X。被认为是食品工业中的废料的文冠果坚果壳是天然抗氧化剂和免疫调节剂的新来源。
The nutshell of Xanthoceras sorbifolia, a waste product in the production of edible oil, is rich in health-promoting phenolic acids. However, the individual constituents, bioactivities, and mechanism of action are largely unknown. In this study, 20 phenolic compounds were characterized in nutshell extract (NE) of X. sorbifolia by gas chromatography-mass spectrometry. Four established in vitro studies showed that NE has significant antioxidant potential. Results in vivo indicated that oral administration of NE effectively ameliorated clinical disease severity of experimental autoimmune encephalomyelitis (EAE) and reduced the neuroinflammation and the central nervous system (CNS) demyelination. The underlying mechanism of NE-induced effects involved decreased penetration of pathogenic immunocyte into the CNS, a reduced production of proinflammatory cytokines and factors, and suppressed differentiation of type 1 T helper and type 17 T helper cells through the Janus kinase/signal transducer and activator of transcription pathway. Taken together, our studies showed that X. sorbifolia nutshell, considered a waste material in the food industry, is a novel source of a natural antioxidant and immunomodulator.