POST-NATAL DEVELOPMENT OF BURST FIRING BEHAVIOR AND THE LOW-THRESHOLD TRANSIENT CALCIUM CURRENT EXAMINED USING FRESHLY ISOLATED NEURONS FROM RAT DORSAL-ROOT GANGLIA
POST-NATAL DEVELOPMENT OF BURST FIRING BEHAVIOR AND THE LOW-THRESHOLD TRANSIENT CALCIUM CURRENT EXAMINED USING FRESHLY ISOLATED NEURONS FROM RAT DORSAL-ROOT GANGLIA
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DOI：
10.1016/0304-3940(89)90306-6
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发表时间：
1989-07-17
影响因子：
2.5
通讯作者：
WHITE, G
中科院分区：
文献类型：
--
作者：
LOVINGER, DM;WHITE, G
爆发式放电是由成年大鼠背根神经节(DRG)最近分离的神经元的后去极化电位(ADP)触发的，在12日龄大鼠的神经元中较少出现，而在1日龄大鼠的神经元中则完全没有。ADP和产生ADP的电压激活瞬时(T-型)钙电流在所有出生后的神经元中都存在，但ADP和T-型电流的幅度在成年神经元中最大，在12日龄动物中较小，在1日龄动物神经元中最小。这些观察结果表明，随着年龄的增长，T型电流的幅度增加，导致幅度增加的ADP的产生，而ADP的那些随年龄发展的特性可能有助于或产生猝发放电行为。
Burst firing was triggered by an afterdepolarizing potential (ADP) in whole-cell recordings from neurons recently isolated from dorsal root ganglia (DRG) of adult rats, less frequently in neurons from 12-day-old rats, and not at all in neurons from 1-day-old rats. Both the ADP and voltage-activated transient (T-type) Ca2+ current which generates the ADP were present in neurons at all postnatal ages; however, the amplitude of the ADP and of the T-type current were greatest in neurons from adults, smaller in neurons from 12-day animals, and smallest in neurons from 1-day animals. These observations suggest that the increase in amplitude of the T-type current with age leads to the generation of an ADP of increased amplitude and those properties of the ADP which develop with age may contribute to or generate burst firing behavior.