Necessity of the glossopharyngeal nerve in the maintenance of normal intake and ingestive bout size of corn oil by rats.
Necessity of the glossopharyngeal nerve in the maintenance of normal intake and ingestive bout size of corn oil by rats.
复制标题
舌咽神经维持大鼠正常摄入玉米油和摄入量的必要性。
DOI：
10.1152/ajpregu.00763.2009
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Spector,AlanC
中科院分区：
文献类型：
--
作者：
Treesukosol,Yada;Blonde,GingerD;Jiang,Enshe;Gonzalez,Dani;Smith,JamesC;Spector,AlanC
最近的文献证据表明，舌咽神经(GL)携带的信号可能是维持正常的对脂肪刺激的味觉反应所必需的，GL为舌后的感觉和副交感神经提供神经支配。在这里，我们报告，与假手术对照组(Sham)相比，GL横切(GLX)显著降低了23小时两瓶试验中玉米油的摄入量和偏爱。对舔玉米油的饮酒模式分析表明，GLX组比Sham大鼠的回合数更小，而不是回合开始的次数。我们还测试了一系列葡萄糖浓度，发现与Sham大鼠相比，GLX大鼠每天23小时的总舔次数显著减少，但当测量摄入量或任何回合参数时，这种差异无法达到显著水平。这些结果表明，GL中的信号通常有助于玉米油回合结束的过程，而不是回合的启动。GL派生的信号可能潜在地为腹侧前脑的“奖赏”回路提供输入，这可能有助于在进餐期间保持摄取，或者，也可以在脑干水平上作用，以减弱迷走神经信号的抑制效力，从而延迟饱腹感的开始，或者可能有助于对肠道的头相反射调制。支配von Ebner腺体的GL中的副交感传出神经也可能在推动玉米油摄入量方面发挥作用。无论是什么机制，一个完整的GL显然是维持玉米油正常摄入量所必需的。
Recent evidence in the literature suggests that signals carried by the glossopharyngeal nerve (GL), which supplies sensory and parasympathetic innervation of the posterior tongue, might be essential in the maintenance of normal gustatory responses to fat stimuli. Here, we report that GL transection (GLX) significantly decreased corn oil intake and preference in 23-h two-bottle tests relative to sham-operated controls (Sham). Drinking-pattern analysis of corn oil licking revealed that bout size, rather than the number of bouts initiated, was smaller in GLX than Sham rats. We also tested a range of glucose concentrations and found that total licks over daily 23-h sessions significantly decreased in GLX compared with Sham rats, but this difference failed to reach significance when intake or any bout parameter was measured. These results show that the signals in the GL normally contribute to processes involved with corn oil bout termination as opposed to bout initiation. GL-derived signals could potentially provide input to “reward” circuits in the ventral forebrain that could serve to maintain ingestion during a meal or, alternatively, could act at the level of the brain stem to attenuate the inhibitory potency of vagal signals, thus delaying the onset of satiation, or perhaps contribute to a cephalic phase reflex modulation of the gut. Parasympathetic efferents in the GL innervating the von Ebner's glands, which secrete lingual lipase, which is thought to break down corn oil into detectable ligands, could also be playing a role in driving corn oil intake. Whatever the mechanism, an intact GL is clearly necessary in maintaining normal intake of corn oil.
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联合而非单一的味觉神经横断显着改变了大鼠对奎宁的味觉引导舔舐行为。
影响因子：
1.9
作者：
S. J. St. John;M. Garcea;A. Spector
通讯作者：
A. Spector
双侧鼓索或舌咽神经切断后的盐味辨别。
DOI：
10.1152/ajpregu.1992.263.1.r169
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Spector,AC;Grill,HJ
通讯作者：
Grill,HJ
DOI：
10.1152/ajpregu.00590.2001
发表时间：
2002-06-01
影响因子：
2.8
作者：
Travers, SP
通讯作者：
Travers, SP
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
舌咽神经和鼓索神经联合横断可提高大鼠（褐家鼠）的奎宁检测阈值。
影响因子：
1.9
作者：
StJohn,SJ;Spector,AC
通讯作者：
Spector,AC