Alteration of electrical activity in molluscan neurones by cyclic nucleotides and peptide factors
Alteration of electrical activity in molluscan neurones by cyclic nucleotides and peptide factors
复制标题
环核苷酸和肽因子改变软体动物神经元的电活动
作者：
S. Treistman;I. Levitan
某些软体动物神经元的电活动受到长时间的突触和激素调节1 - 5。来自几个系统的证据表明，环核苷酸介导神经和肌肉细胞膜特性的改变6 - 8。我们在这里报道，在加利福尼亚海蜗牛和海蜗牛螺旋的某些神经元中，细胞内环核苷酸浓度的增加伴随着电活动的长期变化，并且已知的生理药物可以改变这些神经细胞的电节律，增加螺旋和海蜗牛神经组织中的腺苷3 ',5 ' -环单磷酸腺苷（环AMP）。
ELECTRICAL activity in certain molluscan neurones is subject to long lasting synaptic and hormonal modulation1–5. Evidence from several systems suggests that cyclic nucleotides mediate alterations in membrane properties in nerve and muscle cells6–8. We report here that, in certain neurones from the marine snail Aplysia californica and the land snail Helix pomatia, an increase in the intracellular concentration of cyclic nucleotides is accompanied by long lasting changes in electrical activity, and that physiological agents known to modify the electrical rhythms of these nerve cells, increase adenosine 3′, 5′-cyclic monophosphate (cyclic AMP) in Helix and Aplysia nervous tissue.