Molecular genetic aspects of the citric acid cycle of Escherichia coli.
Molecular genetic aspects of the citric acid cycle of Escherichia coli.
复制标题
大肠杆菌柠檬酸循环的分子遗传学方面。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
J. Guest
中科院分区：
文献类型：
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作者：
J. S. Miles;J. Guest
编码大肠杆菌柠檬酸循环酶的基因已被克隆，并且从核苷酸序列、mRNA转录本和相应基因的定点突变中对这些酶的结构、功能和表达有了很多了解。有氧循环的表达的特殊功能，和它的厌氧转化成一个分支的途径，在兼性厌氧菌，被认为是。本文综述了琥珀酸脱氢酶、琥珀酰辅酶A合成酶、琥珀酸脱氢酶及其相关酶和2-含氧酸脱氢酶复合物的结构与功能关系。
The genes encoding all of the citric acid cycle enzymes of Escherichia coli have been cloned and much has been learned about the structure, function and expression of these enzymes from the nucleotide sequences, the mRNA transcripts and site-directed mutagenesis of the corresponding genes. Special features of the expression of the aerobic cycle, and its anaerobic transformation into a branched pathway in a facultative anaerobe, are considered. Aspects of the structure-function relationships of succinate dehydrogenase, succinyl-CoA synthetase, fumarase and related enzymes, and the 2-oxo acid dehydrogenase complexes are reviewed.