FAMILIAL AGGREGATION OF STREPTOMYCIN OTOTOXICITY - AUTOSOMAL DOMINANT INHERITANCE
FAMILIAL AGGREGATION OF STREPTOMYCIN OTOTOXICITY - AUTOSOMAL DOMINANT INHERITANCE
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DOI：
10.1136/jmg.20.5.357
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发表时间：
1983-01-01
影响因子：
4
通讯作者：
BEIGHTON, P
中科院分区：
文献类型：
--
作者：
VILJOEN, DL;SELLARS, SL;BEIGHTON, P
研究人员调查了来自南非偏远农村地区的一个大型混血家族的8名成员的耳聋情况。在每例患者中，在常规剂量硫酸链霉素抗结核治疗期间发生了严重的永久性感知性听力损失。虽然本研究的现有数据尚未证实，但对链霉素敏感性的家族聚集和分布模式提示常染色体显性遗传。
Eight members of a large kindred of mixed ancestry from a remote rural area of South Africa were investigated for deafness. In each, severe permanent perceptive hearing loss had developed during antituberculous therapy with streptomycin sulfate in conventional doses. Although unproven by the data available in this study, the familial aggregation and pattern of distribution of sensitivity to streptomycin suggested autosomal dominant inheritance.