A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides
A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides
复制标题
DOI：
10.1021/ol9023024
复制
发表时间：
2009-12-03
期刊：
影响因子：
5.2
通讯作者：
Almqvist, Fredrik
中科院分区：
文献类型：
--
作者：
Sellstedt, Magnus;Almqvist, Fredrik
合成了一种具有拟肽骨架结构的新型杂环支架。通过将伯胺插入环状砜中以得到相应的扩环磺酰胺来形成支架。通过改变胺组分，已经合成了一系列具有潜在生物学意义的化合物。
A novel heterocyclic scaffold with a peptidomimetic backbone structure has been synthesized. The scaffold is formed by insertion of primary amines into a cyclic sulfone to give the corresponding ring-expanded sulfonamides. By varying the amine component, a series of potentially biologically interesting compounds has been synthesized.