Fractal characteristics of tumor vascular architecture during tumor growth and regression
Fractal characteristics of tumor vascular architecture during tumor growth and regression
复制标题
DOI：
10.3109/10739689709146803
复制
发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Jain, RK
中科院分区：
文献类型：
--
作者：
Gazit, Y;Baish, JW;Jain, RK
目的：肿瘤血管网不同于正常血管网，但其机制尚不清楚。了解这些机制可能是提高实体瘤治疗效果的关键。方法：我们研究了二维正常和肿瘤血管网络的分形特征生长在小鼠dolsal室制备和成像与活体microscopic station.Results：在肿瘤生长和消退，血管在肿瘤的缩放特性，反映了组织的变化状态。生长中的特纳显示血管网络逐渐偏离其正常模式，其中它们似乎遵循扩散限制。聚集是一种病理状态，在这种状态下，它们显示出与渗流阈值附近的渗流簇相似的缩放。类似放大的比例表明肿瘤血管结构的关键决定因素是局部基质性质，而不是扩散物质（如血管生成生长因子）的梯度。在肿瘤消退期间，脉管系统的分形特征返回到生长肿瘤的分形特征与健康组织的分形特征之间的中间值。以前的研究表明，类似的缩放一般抑制transport.Conclusions：在目前的比赛中，肿瘤血管系统的类似的性质意味着，肿瘤血管网络具有固有的建筑障碍，如氧气和药物的可扩散物质的交付。
Objective: Tumor vascular networks are different from normal vascular networks: but the mechanisms underlying these differences are not known. Understanding these mechanisms may be the key to improving the efficacy of treatment of solid tumors.Methods: We studied the fractal characteristics of two-dimensional normal and tumor vascular networks grown in a murine dol sal chamber preparation and imaged with an intravital microscopy station.Results: During tumor growth and regression, the vasculature in the tumor has scaling characteristics that reflect the changing state of the tissue. Growing turners show vascular networks that progressively deviate from their normal pattern, in which they seem to follow diffusion-limited. aggregation tu a pathological condition in which they display scaling similar to percolation clusters near the percolation threshold. The percolation-like scaling indicates that the key determinants of tumor vascular architecture are local substrate properties rather than gradients of a diffusing substance, such as an angiogenic growth factor. During tumor regression, the fractal characteristics of the vasculature return to an intermediate between those of growing tumors and those of healthy tissues. Previous studies have shown that percolation-like scaling generally inhibits transport.Conclusions: In the present contest, the percolation-like nature of tumor vasculature implies that tumor vascular networks possess inherent architectural obstacles to the delivery of diffusible substances such as oxygen and drugs.