SOMATOMEDIN-C MEDIATES GROWTH-HORMONE NEGATIVE FEEDBACK BY EFFECTS ON BOTH THE HYPOTHALAMUS AND THE PITUITARY
SOMATOMEDIN-C MEDIATES GROWTH-HORMONE NEGATIVE FEEDBACK BY EFFECTS ON BOTH THE HYPOTHALAMUS AND THE PITUITARY
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DOI：
10.1126/science.6262917
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
HINTZ, RL
中科院分区：
文献类型：
--
作者：
BERELOWITZ, M;SZABO, M;HINTZ, RL
生长调节素-C刺激生长抑素释放到最大的基础释放的390%，在短期（20分钟）孵育大鼠下丘脑。在4小时孵育期间，它对大鼠腺垂体细胞原代培养物的基础或刺激生长激素释放没有影响，但在24小时后抑制刺激释放超过90%。这些结果表明，生长调节素-C参与生长激素负反馈回路的下丘脑生长抑素和垂体前叶的延迟效应的即时影响。
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more than 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.