Müller's cell involvement in proliferative diabetic retinopathy.
Müller's cell involvement in proliferative diabetic retinopathy.
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DOI：
10.1001/archopht.1987.01060100126042
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发表时间：
1987-10
影响因子：
--
通讯作者：
T. Nork;I. Wallow;S. Sramek;G. Anderson
中科院分区：
文献类型：
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作者：
T. Nork;I. Wallow;S. Sramek;G. Anderson
为了测试Müller细胞，而不是单独的纤维星形胶质细胞，是否是增殖性糖尿病视网膜病变中的活性胶质细胞成分，我们开发了一种方法，使用碳酸酐酶的酶组织化学分析和胶质细胞酸性蛋白的免疫标记在塑料包埋切片上检测变性视网膜中的Müller细胞。四个死后眼睛增生性糖尿病视网膜病变进行了研究。观察到Müller细胞行为的四个特征：（1）Müller细胞核在视网膜内迁移; (2)它们是视网膜前膜中的主要胶质细胞。(3)Müller细胞在视网膜外层形成水平条带，使其看起来像视网膜下膜。(4)它们在囊状间隙之间形成视网膜内桥。总之，Müller细胞（或其后代）在增殖性糖尿病视网膜病变中起着积极的作用。
To test whether the Müller's cell, and not the fibrous astrocyte alone, is an active glial element in proliferative diabetic retinopathy, we developed a method using enzyme histochemical analysis for carbonic anhydrase and immunolabelling for glial fibrillary acidic protein on plastic-embedded sections to detect Müller's cells in degenerated retinas. Four postmortem eyes with proliferative diabetic retinopathy were studied. Four features of Müller's cell behavior were observed: (1) Müller's cell nuclei migrated within the retina. (2) They were the principal glial cells in preretinal membranes. (3) Müller's cells formed horizontal bands, in the outer retina, that gave the appearance of subretinal membranes. (4) They formed intraretinal bridges between cystic spaces. In conclusion, the Müller's cell (or its progeny) plays an active role in proliferative diabetic retinopathy.