Pulmonary Hypertension Associated with Left-Sided Heart Disease
Pulmonary Hypertension Associated with Left-Sided Heart Disease
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DOI：
10.1016/j.hfc.2012.04.009
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发表时间：
2012-07-01
影响因子：
3.4
通讯作者：
De Marco, Teresa
中科院分区：
文献类型：
--
作者：
Barnett, Christopher F.;De Marco, Teresa
肺动脉高压（Pulmonary hypertension， PH）的血流动力学特征是肺动脉压显著升高，如果持续，可导致临床恶化，导致进行性右侧心力衰竭和死亡。在治疗前确定患者PH的病因是必要的。有效的循证治疗药物治疗PH已开发。然而，关于PH与左侧心力衰竭相关的适当有力的随机试验很少，而且那些已经进行的试验没有显示出益处或危害。迫切需要提高对左心衰相关PH的病理生理学、定义和新疗法的理解。
Pulmonary hypertension (PH) is characterized hemodynamically by significantly elevated pulmonary artery pressure, which if sustained can result in clinical deterioration due to progressive right-sided heart failure and death. Establishing the etiology of PH in a patient before treatment is imperative. Effective evidence-based therapeutic agents for treating PH have been developed. However, appropriately powered, randomized trials in PH associated with left-sided heart failure are sparse, and those that have been performed have shown no benefit or harm. An improved understanding of the pathophysiology, definition, and development of new therapies for treating PH associated with left-sided heart failure is urgently needed.