Anesthesia and the Microcirculation
Anesthesia and the Microcirculation
复制标题
DOI：
10.1177/1089253209353134
复制
发表时间：
2009-12-01
影响因子：
1.4
通讯作者：
Cerny, Vladimir
中科院分区：
文献类型：
--
作者：
Turek, Zdenek;Sykora, Roman;Cerny, Vladimir
越来越多的证据表明，在许多病理条件下，如出血，败血症或创伤，微循环及其调节严重受损。近几十年来，麻醉药对血液动力学的影响被广泛研究。关于现代麻醉剂和麻醉技术的研究增加了关于麻醉剂的非麻醉作用的知识，包括对器官灌注和微循环的影响。微血管反应性、一氧化氮通路和细胞因子释放的改变可能是麻醉诱导的组织灌注变化的主要机制。本文综述了目前的微循环状态评估方法和目前的知识，静脉和有效的挥发性麻醉药和麻醉相关技术在正常和病理生理条件下的微循环影响。
There is increasing evidence that the microcirculation and its regulation are severely compromised during many pathological conditions, such as hemorrhage, sepsis, or trauma. The effects of anesthetic agents on macrohemodynamics were investigated intensively in the last several decades. Research regarding modern anesthetics and anesthesia techniques has increased knowledge regarding the nonanesthetic effects of anesthetic agents, including those on organ perfusion and the microcirculation. Alterations in microvascular reactivity, nitric oxide pathways, and cytokine release are presumably the main mechanisms of anesthetic-induced tissue perfusion changes. This review summarizes current methods of microcirculatory status assessment and current knowledge regarding the microcirculatory effects of intravenous and potent volatile anesthetics and anesthesia-related techniques under both normal and pathophysiological conditions.