Abnormal Water Diffusivity in Corticostriatal Projections in Children With Tourette Syndrome
Abnormal Water Diffusivity in Corticostriatal Projections in Children With Tourette Syndrome
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DOI：
10.1002/hbm.20970
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发表时间：
2010-11-01
影响因子：
4.8
通讯作者：
Chugani, Harry T.
中科院分区：
文献类型：
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作者：
Govindan, Rajkumar Munian;Makki, Malek I.;Chugani, Harry T.
前额-纹状体-丘脑环路与多发性抽动症(TS)的发病机制有关为了全面研究白质和灰质，我们使用了一种新的技术，即基于区域的空间统计(TBSS)和基于体素的分析(VBA)，对TS儿童的扩散张量磁共振图像进行了比较。这些自动化和无偏见的方法可以分析大脑白质和灰质区域。我们比较了15名患有TS的右利手儿童(平均年龄116+/-2.5岁，男性12名)和14名年龄匹配的右利手健康对照组(NC，平均年龄：12.29+/-3.2岁，6名男性)。抽动严重程度和神经行为评分与FA和ADC值相关。对于白质，TBSS分析显示与NC组相比，TS组皮质纹状体投射通路包括左侧外囊和左侧和右侧穹隆下束通路的ADC值增加。在TS组中，左侧外囊ADC值与灰质抽动严重程度呈负相关(r=-0.586，P=0.02)，VBA显示双侧眶前叶皮质、左侧壳核和左侧岛叶皮质ADC值升高，右侧和左侧眶前叶皮质ADC值与内化问题高度相关(分别为r=0.665，P=0.009，r=0.545；P=0.04)，提示TS患者皮质纹状体通路和参与额纹环路的灰质结构局部弥散异常。这些弥散异常可作为TS患者抽动严重程度和神经行为异常的神经影像标志物。《哼唱大脑地图》31.1665-1674年，2010年。(C)2010年Wiley-Liss公司
The fronto-striato-thalamic circuit has been implicated in the pathomechanism of Tourette Syndrome (TS) To study white and gray matter comprehensively, we used a novel technique called Tract-Based Spatial Statistics (TBSS) combined with voxel-based analysis (VBA) of diffusion tensor MR images in children with TS as compared to typically developing controls. These automated and unbiased methods allow analysis of cerebral white matter and gray matter regions. We compared 15 right-handed children with TS (mean age 11 6 +/- 2.5 years, 12 males) to 14 age-matched right-handed healthy controls (NC, mean age: 12.29 +/- 3.2 years, 6 males). Tic severity and neurobehavioral scores were correlated with FA and ADC values in regions found abnormal by these methods. For white matter, TBSS analysis showed regions of Increased ADC in the corticostriatal projection pathways including left external capsule and left and right subcallosal fasciculus pathway in TS group compared to NC group. Within the TS group, ADC for the left external capsule was negatively associated with tic severity (r = -0 586, P = 0 02) For gray matter, VBA revealed increased ADC for bilateral orbitofrontal cortex, left putamen, and left insular cortex ADC for the right and left orbitofrontal cortex was highly correlated with internalizing problems (r = 0.665, P = 0 009, r = 0 545; P = 0 04, respectively) Altogether, this analysis revealed focal diffusion abnormalities in the corticostriatal pathway and in gray matter structures involved in the fronto-striatal circuit in TS. These diffusion abnormalities could serve as a neuroimaging marker related to tic severity and neurobehavioral abnormalities in TS subjects. Hum Brain Mapp 31.1665-1674, 2010. (C) 2010 Wiley-Liss, Inc.