Hepatitis C virus as a causative agent of hepatocellular carcinoma.
Hepatitis C virus as a causative agent of hepatocellular carcinoma.
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丙型肝炎病毒是肝细胞癌的病原体。
DOI：
10.1159/000150427
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发表时间：
1995
期刊：
影响因子：
4.6
通讯作者：
K. Shimotohno
中科院分区：
文献类型：
--
作者：
K. Shimotohno
流行病学研究表明，HCV感染与肝细胞癌的发生密切相关。然而，HCV致癌的机制知之甚少。与其他人类致癌病毒不同，HCV是典型的RNA病毒，因此病毒基因组或基因组片段不整合到宿主染色体中。此外，由其他人类致癌病毒编码并主要为病毒复制所需且通常参与细胞永生化的反式作用转录因子可能不由HCV编码。虽然在HCV感染的肝脏中，肝细胞的再生可能是将肝细胞推向恶性阶段的首要因素，但HCV还可能存在其他未知的致癌功能。因此，应强调阐明病毒在肝细胞中复制的分子机制。
HCV infection has shown to be strongly linked to the development of hepatocellular carcinoma in epidemiological studies. However, the mechanism of carcinogenesis by HCV is poorly understood. Unlike other human oncogenic viruses, HCV is a typical RNA virus, and thus there is no integration of the viral genome or a piece of the genome into host chromosomes. Moreover, trans-acting transcriptional factors which are coded by other human oncogenic viruses and required primarily for virus replication and often involved in cell immortalization, may not be coded by HCV. Although regeneration of hepatocytes in an HCV-infected liver may be of primary importance in driving hepatocytes to the malignant stage, an additional unknown carcinogenic function of HCV may also exist. For this reason, clarification of the molecular mechanism of virus replication in hepatocytes should be emphasized.