Schistosomiasis in the Senegal river basin: Before and after the construction of the dams at Diama, Senegal and Manantali, Mali and future prospects
Schistosomiasis in the Senegal river basin: Before and after the construction of the dams at Diama, Senegal and Manantali, Mali and future prospects
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DOI：
10.1017/s0022149x00015790
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发表时间：
1997-06-01
影响因子：
1.6
通讯作者：
Southgate, VR
中科院分区：
文献类型：
--
作者：
Southgate, VR
塞内加尔河流域的生态变化是人类血吸虫病流行病学变化的原因，这些变化是由于在塞内加尔河上的迪亚马建造了一座拦河坝以防止海水侵入该河，以及在巴芬河上的马南塔利建造了一座大坝以控制水流和发电。将曼氏血吸虫引入SRB的下谷和中谷以及随后寄生虫在人群中的传播记录在流行率和强度方面。S.描述了产血吸虫。海水盐度的降低和环境由酸性转为碱性，有利于淡水螺的繁殖和生长，也有利于寄生虫的传播。新灌溉渠的修建和稻田的扩大为中间宿主提供了新的栖息地。吡喹酮耐药/耐受性的证据S。并讨论了研制、生产和检验人血吸虫病疫苗的可能性。未来的研究将监测人尿和肠系膜血吸虫病在SRB中的传播，将进一步评估S.曼森尼将检查严重感染人群的病理症状，并确定控制这场严重人类血吸虫病爆发的最适当方法。
Ecological changes in the Senegal River Basin (SRB) resulting from the construction of a barrage at Diama, Senegal on the Senegal River to prevent the intrusion of sea water into the river, and a dam at Manantali, Mall on the Bafing River to control the flow of water and to generate electricity, have been responsible for changes in the epidemiology of human schistosomiasis. The introduction of Schistosoma mansoni into the Lower and Middle Valleys of the SRB and subsequent spread of the parasite in the human population is recorded with regard to prevalence and intensity. New foci of S. haematobium are described. The reduction in salinity and change from an acidic to an alkaline environment in the water are beneficial to both the fecundity and growth of freshwater snails and transmission of the parasite. The creation of new irrigation canals and expansion of the rice fields have provided new habitats for intermediate hosts to colonize. The evidence for praziquantel resistance/tolerance by populations of S. mansoni and the possibilities of the development, production and testing of a vaccine against human schistosomiasis are discussed. Future studies will monitor the spread of human urinary and mesenteric schistosomiasis in the SRB, will evaluate further the presence of praziquantel resistance/tolerance in S. mansoni, will examine the heavily infected human population for pathological symptoms and determine the most appropriate methods to control this severe outbreak of human schistosomiasis.