Urinary cortisol excretion as a predictor of incident cognitive impairment.
Urinary cortisol excretion as a predictor of incident cognitive impairment.
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DOI：
10.1016/j.neurobiolaging.2005.09.037
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Seeman, Teresa E
中科院分区：
文献类型：
--
作者：
Karlamangla, Arun S;Singer, Burton H;Seeman, Teresa E
糖皮质激素水平升高与认知障碍有关，包括痴呆。然而，很少有纵向研究探讨了静息皮质醇水平和认知障碍发生率之间的关系。我们于1988年测量了538名70-79岁的高功能男性和女性的皮质醇夜间尿排泄量，并于1988年、1991年和1995年使用简短的便携式精神状态问卷（SPMSQ）评估了他们的认知功能。与基线时尿皮质醇最低四分位数的参与者相比，在7年随访中，前三个四分位数的参与者发生认知障碍的风险更高（即，SPMSQ评分下降至低于6分（满分9分）。这种关联不受年龄、性别、教育水平、种族、吸烟、流行心血管疾病和血压调整的影响（最高四分位数的调整优势比为2.34，95%置信区间为1.07-5.14）。没有性别的影响修改;该协会是同样强大的男性和女性。我们的结论是，尿皮质醇排泄预测事件认知功能障碍的老年男性和女性。
Elevated glucocorticoid levels have been associated with cognitive impairment, including dementia. However, few longitudinal studies have examined the association between resting cortisol levels and the incidence of cognitive impairment. We measured overnight urinary excretion of cortisol in 538 high-functioning men and women, 70-79 years of age, in 1988, and assessed their cognitive functioning in 1988, 1991, and 1995 using the short portable mental status questionnaire (SPMSQ). Compared to participants in the bottom quartile of urinary cortisol at baseline, those in the top three quartiles had higher risk of incident cognitive impairment over the 7-year follow up (i.e., decline in SPMSQ score to below six out of nine). This association was not affected by adjustment for age, gender, education level, ethnicity, smoking, prevalent cardiovascular disease, and blood pressure (adjusted odds ratio for the highest quartile 2.34, 95% confidence interval, 1.07-5.14). There was no effect modification by gender; the association was equally strong in men and women. We conclude that urinary excretion of cortisol predicts incident cognitive impairment in older men and women.