Characteristics of reactive oxygen metabolites in serum of early teenagers in Japan
Characteristics of reactive oxygen metabolites in serum of early teenagers in Japan
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DOI：
10.1007/s12199-011-0261-7
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发表时间：
2012-09
影响因子：
4.7
通讯作者：
Terumi Kogawa;M. Nishimura;S. Kurauchi;I. Kashiwakura
中科院分区：
文献类型：
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作者：
Terumi Kogawa;M. Nishimura;S. Kurauchi;I. Kashiwakura
目的对血液中氧化应激状态与心血管疾病发病的关系进行了一定程度的研究。一些证据强调了从儿童时期开始对心血管疾病进行一级预防的重要性。然而，人们对儿童时期氧化应激的现状知之甚少。本研究进行了，以确定活性氧代谢产物（ROM）的水平在早期的青少年血清中的当前状态。MethodsThis研究招募了595名健康的初中学生从位于北方日本南部镇。结果女生ROM水平[308.6 ± 63.1 U.卡尔单位（CARR）]略高于男生[299.9 ± 55.2 U.卡尔单位（CARR）]，但差异无统计学意义。男性BAP水平显著高于女性。一年级男生ROM和BAP水平高于其他年级。在女性中，只有一年级学生的BAP高于其他grade.ConclusionsThe目前的研究发现，男性的ROM水平与年级呈负相关。这些结果表明，在日本青春期存在增加氧化应激的因素。
ObjectivesThe relationship between the incidence of cardiovascular disease and the state of oxidative stress in blood has been studied to some extent. Several lines of evidence underscore the importance of primary prevention of cardiovascular disease beginning in childhood. However, little is known about the current state of oxidative stress in childhood. This study was carried out to determine the current state of the level of reactive oxygen metabolites (ROM) in serum of early teenagers.MethodsThis study enrolled 595 healthy junior high school students from the town of Nanbu located in northern Japan. Oxidative stress was evaluated by measuring the serum level of ROM, and antioxidant capacity was evaluated by measuring the serum level of biological antioxidant potential (BAP).ResultsAlthough the ROM level in female students [308.6 ± 63.1 Carratelli units (U.CARR)] was slightly higher than that in males (299.9 ± 55.2 U.CARR), the difference was not statistically significant. The BAP level in males was significantly higher than that in females. The levels of ROM and BAP detected in males in the first grade were higher than those in the other grades. In females, only first-graders’ BAP was higher than that in other grades.ConclusionsThe current study found that the ROM level in males was negatively correlated with grade. These results suggest the presence of factor(s) that increase oxidative stress in Japanese puberty.