Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat:: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons
Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat:: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons
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DOI：
10.1002/cne.10789
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发表时间：
2003-10-06
影响因子：
2.5
通讯作者：
Arendt, T
中科院分区：
文献类型：
--
作者：
Härtig, W;Riedel, A;Arendt, T
大鼠伏隔核尾侧壳的谷氨酸泡转运蛋白1 （VGLUT1）和谷氨酸泡转运蛋白2 （VGLUT2）分布不均匀。本文的重点是VGLUT1和VGLUT2的模式是否对应于尾尾壳区域的细胞结构和细胞化学定义的亚区域。VGLUT2被证明与calretinin在已知从室旁丘脑核发出的密集轴突丛中共表达。在被称为走廊的区域，被这种室旁丘脑神经支配所保留，轴突终末被发现聚集和vglut1免疫反应。假设这些纤维起源于边缘前皮层和/或细胞旁基底杏仁核，已知其投射到伏隔壳成分。我们的研究结果证实，在尾侧壳中存在两个分离良好的神经元回路，它们由两个不同的兴奋性输入系统主导，这些输入系统来自丘脑、皮层或皮层样杏仁核。大的侧廊——不仅在VGLUT1免疫标记方面，而且在钙结合蛋白阳性细胞的含量方面与伏隔核相似——可能代表解剖学上定义较弱的伏隔岸区。(C) 2003 Wiley-Liss, Inc。
The caudomedial shell of the rat nucleus accumbens exhibits inhomogeneous distribution patterns of the vesicular glutamate transporters 1 (VGLUT1) and 2 (VGLUT2). This paper focuses on the question of whether patterns of VGLUT1 and VGLUT2 correspond to cytoarchitectonically and cytochemically defined subterritories of the caudomedial shell region. VGLUT2 was shown to be coexpressed with calretinin in the dense axonal plexus known to emanate from the paraventricular thalamic nucleus. In regions termed corridors, which are spared by this paraventricular thalamic innervation, axonal terminals were found to be clustered and VGLUT1-immunoreactive. It is assumed that these fibers originate in the prelimbic cortex and/or in the parvicellular basal amygdaloid nucleus known to project to accumbal shell components. Our findings confirm the existence of two well-separated neuronal circuits in the caudomedial shell that are dominated by two different excitatory input systems originating from either thalamic, cortical, or cortex-like amygdaloid sources. The large lateral corridors-which resemble the accumbal core not only in respect to their VGLUT1 immunolabeling but also concerning their content of calbindin-positive cells-may represent a component of the anatomically weakly defined accumbal shore region. (C) 2003 Wiley-Liss, Inc.