Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced?
Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced?
复制标题
视网膜母细胞瘤幸存者中的第二种非眼部肿瘤。
DOI：
10.1016/s0161-6420(84)34127-6
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发表时间：
1984
期刊：
影响因子：
13.7
通讯作者：
George Tung
中科院分区：
文献类型：
--
作者：
D. Abramson;R. Ellsworth;F. D. Kitchin;George Tung
对 693 名双侧视网膜母细胞瘤患者和 18 名单侧/生殖视网膜母细胞瘤患者进行了回顾，以了解视网膜母细胞瘤幸存者中第二个非眼部肿瘤的发生率、时间、病程和模式。在 688 名视网膜母细胞瘤放射治疗中幸存的患者中，89 名患者出现了第二个肿瘤：62 名在放射区，27 名在放射区外。在 23 名未接受放射治疗的患者中，有 5 名患者出现了第二个肿瘤：一名在野外，四名在野外。最常见的肿瘤是放射野内外的肉瘤。尽管平均潜伏期为 10.4 年，但第二肿瘤的发生率随着时间的推移而增加。 10岁时，第二次肿瘤的发生率为20%，20岁时为50%，30岁时为90%。未接受放射治疗且肿瘤在野外发生的患者的肿瘤发生率在 10 年时为 10%，在 20 年时为 30%，在 32 年时为 68%。当用生命表分析时，肿瘤发生率与治疗辐射剂量之间没有关系。第二个疗程的放射治疗并没有增加第二个非眼部肿瘤的发生率。
A review of 693 patients with bilateral retinoblastoma and 18 patients with unilateral/germinal retinoblastoma was carried out to find the incidence, time, course and pattern of second nonocular tumors in retinoblastoma survivors. Of 688 patients who survived therapeutic radiation for retinoblastoma, 89 developed second tumors: 62 in the field of radiation and 27 out of the field. Of 23 patients who received no radiation, five developed second tumors: one in the field and four out of the field. The most common tumor found was a sarcoma both in and out of the field of radiation. The incidence of second tumors increases with time, although the mean latent period is 10.4 years. At 10 years, the incidence of second tumors is 20%, at 20 years, it is 50% and at 30 years, 90%. The incidence of tumors in patients treated without radiation and where tumors developed outside the field was 10% at 10 years, 30% at 20 years and 68% at 32 years. There was no relationship between incidence of tumors and dose of therapeutic radiation when analyzed with life tables. A second course of radiation therapy did not increase the incidence of second nonocular tumors.