DEVELOPMENT OF CARCINOGEN-INDUCED SKIN TUMORS IN MICE WITH VARIED STATES OF IMMUNE CAPACITY
DEVELOPMENT OF CARCINOGEN-INDUCED SKIN TUMORS IN MICE WITH VARIED STATES OF IMMUNE CAPACITY
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DOI：
10.1002/ijc.2910260114
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
OUTZEN, HC
中科院分区：
文献类型：
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作者：
OUTZEN, HC
在免疫能力中等的小鼠身上，经MCA处理的皮肤移植到免疫功能最强的小鼠身上，在不同程度上恢复正常的脾细胞，肿瘤形成的发生率明显高于免疫能力最低或最大的小鼠。将MCA处理过的皮肤移植到免疫能力不同的小鼠身上，观察到类似的双相肿瘤发病曲线，这些小鼠是由胸腺切除和不同剂量的全身照射产生的。接受中等剂量照射的小鼠比接受高剂量或低剂量照射的小鼠发生的肿瘤要多得多。通过测量同种异体皮肤移植排斥反应时间，证明了这两种方法实际上都能够诱导不同水平的免疫活性。免疫调节的小鼠有皮肤移植排斥反应的次数，这与转移到其中的具有免疫功能的脾细胞的数量密切相关。同基因正常乳腺上皮细胞移植到清除的乳腺脂肪垫中的生长潜力在免疫改变的小鼠和正常对照小鼠中相似，表明免疫改变的小鼠和正常对照小鼠同样能够支持移植的正常组织的生长。这些结果与免疫刺激假说的预测一致，表明免疫反应能够刺激和抑制肿瘤的发生。
The incidence of tumor formation in MCA[methylcholanthrene]-treated skin grafted onto maximally immunosuppressed mice that had been restored to varying extents with normal spleen cells was significantly greater in the mice with intermediate immune capacities than in those that had minimal or maximal capacities. A similar biphasic tumor incidence curve was observed when MCA-treated skin was grafted onto mice of varying immune capacities, produced by thymectomy and varying doses of whole-body irradiation. Significantly more tumors occurred in the mice given moderate doses of irradiation than in those given higher or lower doses. That both of these procedures were actually able to induce discrete levels of immunocompetence was demonstrated by measuring skin allograft rejection times. The immunomodulated mice had skin graft rejection times which strongly correlated with the number of immunologically competent spleen cells transferred into them. The outgrowth potential of syngeneic normal mammary epithelial cells grafted into cleared mammary fat pads was similar in immunologically altered and normal control mice, showing that immunoaltered and normal control mice were equally able to support the growth of transplanted normal tissues. These results, which conform with the predictions of the immunostimulation hypothesis, suggest that the immune response is able to stimulate and inhibit oncogenesis.