Receptive-field maps of correlated discharge between pairs of neurons in the cat's visual cortex.
Receptive-field maps of correlated discharge between pairs of neurons in the cat's visual cortex.
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猫视觉皮层神经元对之间相关放电的感受野图。
DOI：
10.1152/jn.1994.71.1.330
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发表时间：
1994
影响因子：
2.5
通讯作者：
Freeman,RD
中科院分区：
文献类型：
--
作者：
Ghose,GM;Ohzawa,I;Freeman,RD
1.为了研究视觉皮层中邻近细胞之间时间相关放电的功能意义，我们获得了小猫和猫的68个细胞对的相关放电的感受野图。通过单个细胞外电极测量来自细胞对的放电。一个反向相关程序被用来将神经放电与短暂闪烁的亮条和暗条的随机序列内的特定刺激相关联。双细胞感受野（BRFs）映射应用反向相关近似同步放电从两个细胞。单细胞感受野（URFs）的同时映射分别应用反向相关的每个细胞的放电。2.每对中的两个神经元的感受野最初通过改变漂移正弦光栅的方向和空间频率来研究。在这些测试之后，使用适当定向的杆的随机序列来引起适合于反向相关分析的放电。对于大多数细胞对，由这种刺激产生的相关放电的时间模式或强度与通过正弦光栅刺激观察到的不同。这表明视觉诱发的附近细胞之间的相关放电是刺激依赖性的。3. BRFs根据其空间敏感性模式分为三组，大致对应于外侧膝状体核（LGN;中心环绕）和视觉皮层（简单和复杂）的单细胞感受野类型。这些分类进行了比较，在每对单细胞的感受野类型。LGN型和简单型BRF仅见于其中至少一个细胞是简单的细胞对。相反，复合型BRF仅见于其中至少一个细胞是复合的细胞对。4.由于反向相关过程可以用来表征简单细胞的时空感受场结构，我们能够比较与简单细胞对的URF和BRF相关的空间和时间特性。一个简单的细胞对的BRF的时空结构可以在很大程度上预测的基础上的两个URF。虽然这一预测表明，BRF是刺激文物的可能性，洗牌程序，其中多次重复的随机序列，验证了BRF的神经起源。BRF来自特定的神经通路，而不仅仅是单细胞反应偏好的结果。5.从简单细胞感受野的反向相关分析中获得了五个指标：宽度、持续时间、最佳空间和时间频率以及最佳速度。（400字处截断摘要）
1. To investigate the functional significance of temporally correlated discharge between nearby cells in the visual cortex, we obtained receptive-field maps of correlated discharge for 68 cell pairs in kittens and cats. Discharge from cell pairs was measured by a single extracellular electrode. A reverse correlation procedure was used to relate neural discharge to particular stimuli within a random sequence of briefly flashed bright and dark bars. Bicellular receptive fields (BRFs) were mapped by applying reverse correlation to approximately synchronous discharge from two cells. Unicellular receptive fields (URFs) were simultaneously mapped by separately applying reverse correlation to the discharge of each cell. 2. The receptive fields of the two neurons within each pair were initially studied by varying the orientation and spatial frequency of drifting sinusoidal gratings. After these tests a random sequence of appropriately oriented bars was used to evoke discharge suitable for reverse correlation analysis. For most cell pairs, the temporal pattern or strength of correlated discharge produced by such stimulation is different from that observed with stimulation by sinusoidal gratings. This indicates that visually evoked correlated discharge between nearby cells is stimulus dependent. 3. BRFs were classified according to their pattern of spatial sensitivity into three groups that roughly correspond to the single-cell receptive-field types of the lateral geniculate nucleus (LGN; center-surround) and visual cortex (simple and complex). These classifications were compared with the receptive-field types of the single cells within each pair. LGN-type and simple-type BRFs were only seen for pairs in which at least one of the cells was simple. Conversely, complex-type BRFs were only seen for pairs in which at least one of the cells was complex. 4. Because the reverse correlation procedure can be used to characterize the spatiotemporal receptive-field structure of simple cells, we were able to compare both the spatial and temporal properties associated with the URFs and BRFs of simple cell pairs. The spatiotemporal structure of the BRF of a simple-cell pair can largely be predicted on the basis of the two URFs. Although this prediction suggests the possibility that BRFs are stimulus artifacts, a shuffle procedure, in which multiple repetitions of random sequences were presented, verifies the neural origin of BRFs. BRFs emerge from specific neural pathways and are not simply a consequence of unicellular response preferences. 5. Five measures were derived from the reverse correlation analysis of simple-cell receptive fields: width, duration, optimal spatial and temporal frequency, and optimal velocity.(ABSTRACT TRUNCATED AT 400 WORDS)