EFFECT OF DOPA ON SPINAL CORD .5. RECIPROCAL ORGANIZATION OF PATHWAYS TRANSMITTING EXCITATORY ACTION TO ALPHA MOTONEURONES OF FLEXORS AND EXTRNSORS
EFFECT OF DOPA ON SPINAL CORD .5. RECIPROCAL ORGANIZATION OF PATHWAYS TRANSMITTING EXCITATORY ACTION TO ALPHA MOTONEURONES OF FLEXORS AND EXTRNSORS
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DOI：
10.1111/j.1748-1716.1967.tb03636.x
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发表时间：
1967-01-01
期刊：
影响因子：
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通讯作者：
LUNDBERG, A
中科院分区：
文献类型：
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作者：
JANKOWSKA, E;JUKES, MGM;LUNDBERG, A
在未麻醉的脊髓猫中，注射左旋多巴，屈肌反射传入（FRA）的齐射在同侧屈肌和对侧伸肌运动神经元中引起长潜伏期、长持续放电。据推测，这种放电是通过神经元通路传递的，该通路在正常急性脊髓猫中被抑制，推测来自该通路，该通路在这种状态下将短潜伏期效应从FRA传递到运动神经元。通过记录屈肌和伸肌传出神经的放电和运动神经元的细胞内记录，分析了注射多巴释放的通路的组织。联合刺激同侧和对侧FRA揭示了一个互惠的组织，无论是屈肌或伸肌运动神经元被激活。在对侧FRA，截击可抑制同侧FRA向屈肌运动神经元的传递，在同侧FRA，截击可抑制对侧FRA向伸肌运动神经元的传递。这些抑制作用既不是在运动神经元中突触后产生的，也不是通过初级传入神经的去极化在突触前产生的，因此在神经元间水平产生。在神经元间水平的相互inervatton的组织进行了讨论，在多巴后，在LA传入末梢和节律性交替运动诱发的初级传入去极化。
In unanesthettzed spinal cats, injected with L-DOPA, volleys in the flexor reflex afferents (FRA) evoke a long-latency, longlasting discharge in ipsilateral flexor and contralateral extensor motoneurones. It is postulated that this discharge is transmitted by a neuronal pathway which is inhibited in the normal acute spinal cat, presumable from the pathway, which in this state transmits the short latency effect from the FRA to motoneurones. The organization of the pathway released by an injection of DOPA has been analyzed by recording the discharges in efferents to flexors and extensors and with intracellular records from motoneurones. Combined stimulation of ipsilateral and contralateral FRA reveals a reciprocal organization in that either flexor or extensor motoneurones are activated. Transmission from the ipsilateral FRA to flexor motoneurones can be inhibited by volleys in the contralateral FRA, and transmission from the contralateral FRA to extensor motoneurones by volleys in the ipsilateral FRA. These inhibitory effects are neither produced post-synaptically in the motoneurones nor presynapttcally by depolarization of primary afferents and are hence exerted at an interneuronal level. The organization of reciprocal innervatton at an interneuronal level is discussed in relation to the primary afferent depolarization evoked in la afferent terminals after DOPA and to rhythmic alternating movements.