Functional connectivity between the left and right inferior frontal lobes in a small sample of children with and without reading difficulties
Functional connectivity between the left and right inferior frontal lobes in a small sample of children with and without reading difficulties
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DOI：
10.1080/13554794.2010.532141
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发表时间：
2011-01-01
期刊：
影响因子：
0.8
通讯作者：
Black, Jeffrey
中科院分区：
文献类型：
--
作者：
Farris, Emily A.;Odegard, Timothy N.;Black, Jeffrey
患有阅读障碍的人在完成基本的阅读任务时，经常表现出双侧额叶下部的激活。为了调查这些发现，功能连接分析进行了功能磁共振成像数据收集的阅读障碍儿童，谁没有和没有反应良好的治疗，并从非受损的读者。对15名参与者的活动和静息状态fMRI数据的分析显示，非受损读者和治疗反应者的下额叶区域之间存在功能联系，但在治疗无反应者中则没有。结合DTI数据的分析显示与胼胝体前部结构相关。这些结果表明，双侧额叶功能连接是规范的，可能有助于治疗反应。
Individuals with dyslexia often demonstrate bilateral inferior frontal lobe activation while performing basic reading tasks. To investigate these findings, functional connectivity analyses were conducted on fMRI data collected from children with dyslexia, who did and did not respond well to treatment, and from non-impaired readers. Analysis of active and resting-state fMRI data across 15 participants revealed functional connections between the inferior frontal regions in non-impaired readers and treatment responders, but not in treatment non-responders. Analyses incorporating DTI data revealed associations with anterior corpus callosum structures. These results suggest that bilateral frontal functional connectivity is normative and may facilitate treatment response.