Neurons sensitive to interaural temporal disparities in the medial part of the ventral nucleus of the lateral lemniscus.

Neurons sensitive to interaural temporal disparities in the medial part of the ventral nucleus of the lateral lemniscus.
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对外侧丘系腹侧核内侧部分的耳间时间差异敏感的神经元。

DOI:
10.1152/jn.1997.78.1.511
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发表时间:
1997
期刊:
Journal of neurophysiology.
影响因子:
--
通讯作者:
Fitzpatrick,DC
Fitzpatrick,DC
中科院分区:
--
文献类型:
--
作者:
Batra,R;Fitzpatrick,DC

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Batra,Ranjan和道格拉斯C.菲茨帕特里克.神经元对耳间颞叶差异敏感的外侧丘系腹侧核内侧部分.神经生理学杂志. 78:511-515,1997.外侧丘系腹侧核(VNLL)参与处理单耳声音,因为其神经元主要接受来自对侧耳蜗核的输入。然而,我们在这里表明,VNLL的区域包含一个独特的人口的神经元,处理双耳的声音和耳间的时间差异(ITDs)敏感。用金属电极或装有生物素或荧光标记葡聚糖的微量移液器记录未麻醉家兔单个神经元的反应。重建记录网站的基础上的一些标志表明,ITD敏感神经元位于内侧区域的VNLL,具有低密度的神经元或在相邻的网状结构。在一只动物中,5个ITD敏感神经元的位置直接通过注射具有不同标签的葡聚糖来标记。这些神经元均位于VNLL的内侧区。VNLL的ITD敏感神经元具有特征性反应。大多数神经元只在发病时对侧或双耳提出的音调,许多没有响应同侧刺激单独,并没有遵循ITD的动态变化。ITD敏感神经元的VNLL,只在发病的音调反应的存在表明,这个中心在本地化的瞬态声音中发挥作用。
Batra, Ranjan and Douglas C. Fitzpatrick.Neurons sensitive to interaural temporal disparities in the medial part of the ventral nucleus of the lateral lemniscus.J. Neurophysiol.78: 511–515, 1997. The ventral nucleus of the lateral lemniscus (VNLL) is implicated in processing monaural sounds, because its neurons receive input chiefly from the contralateral cochlear nucleus. However, we demonstrate here that a region of the VNLL contains a distinct population of neurons that process binaural sounds and are sensitive to interaural temporal disparities (ITDs). Responses of single neurons were recorded from unanesthetized rabbits by using metal electrodes or micropipettes loaded with dextran tagged with either biotin or a fluorescent label. Reconstructions of recording sites based on a few marks indicated that ITD-sensitive neurons were located in a medial region of VNLL that has a low density of neurons or in the adjacent reticular formation. In one animal the locations of five ITD-sensitive neurons were marked directly by injection of dextrans with different tags. All of these neurons lay in the medial region of the VNLL. The ITD-sensitive neurons of the VNLL had characteristic responses. Most neurons responded only at the onset of contralaterally or binaurally presented tones; many did not respond to ipsilateral stimulation alone and did not follow dynamic changes in the ITD. The presence of ITD-sensitive neurons in the VNLL that responded only at the onset of tones suggests that this center plays a role in the localization of transient sounds.
DOI: 10.1152/jn.1993.69.3.842
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