Nonlinear analysis of sequence symmetry of beta-trefoil family proteins
Nonlinear analysis of sequence symmetry of beta-trefoil family proteins
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DOI：
10.1016/j.chaos.2004.11.049
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发表时间：
2005-07-01
影响因子：
7.8
通讯作者：
Xiao, Y
中科院分区：
文献类型：
--
作者：
Li, MF;Huang, YZ;Xiao, Y
β-三叶家族蛋白质的三级结构具有三重准对称性，而其氨基酸序列几乎是随机出现的。在本文中，我们表明，这些氨基酸序列实际上有隐藏的对称性，而且这些隐藏的对称性的程度是相同的，它们的三级结构。我们将提出一个修改后的递归图，揭示隐藏的对称性蛋白质序列。我们的结果可以解释β-三叶家族蛋白质序列-结构关系的矛盾。(c)2005爱思唯尔有限公司保留所有权利。
The tertiary structures of proteins of beta-trefoil family have three-fold quasi-symmetry while their amino acid sequences appear almost at random. In the present paper we show that these amino acid sequences have hidden symmetries in fact and furthermore the degrees of these hidden symmetries are the same as those of their tertiary structures. We shall present a modified recurrence plot to reveal hidden symmetries in protein sequences. Our results can explain the contradiction in sequence-structure relations of proteins of beta-trefoil family. (c) 2005 Elsevier Ltd. All rights reserved.