Pharmacotherapeutic treatment of panic disorder in patients presenting with chest pain.
Pharmacotherapeutic treatment of panic disorder in patients presenting with chest pain.
复制标题
胸痛患者惊恐障碍的药物治疗。
DOI：
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发表时间：
1989
影响因子：
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通讯作者：
S. Anderson
中科院分区：
文献类型：
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作者：
B. Beitman;I. Basha;L. Trombka;M. A. Jayaratna;Barbara Russell;G. Flaker;S. Anderson
虽然患有惊恐障碍的精神病患者对几类精神活性药物有反应，但几乎没有证据表明患有惊恐障碍的医学患者对类似的干预措施有反应。在这项为期8周的非盲法阿普唑仑试验中，20名胸痛患者中有15名患有惊恐障碍，其中15名符合改善的单一标准：惊恐频率减少50%或更多。其他几项指标对完成研究的人也有显著的积极影响。此外，这些患者报告胸痛或不适发作略有显著下降。现在需要进行一项双盲、安慰剂对照试验来检验这些发现的有效性。
While psychiatric populations with panic disorder have been shown to be responsive to several classes of psychoactive medications, there is little evidence that medical patients with panic disorder respond to similar interventions. In this non-blind, eight-week trial of alprazolam in patients presenting with chest pain and found to have panic disorder, 15 of 20 met the single criterion for improvement: a 50 percent or greater reduction in panic frequency. Several other measures were also significantly positive for those who completed the study. Furthermore, these patients reported a marginally significant drop in episodes of chest pain or discomfort. A double-blind, placebo-controlled trial is now required to test the validity of these findings.