Vascular endothelial growth factor and placenta growth factor in intrauterine growth-restricted fetuses and neonates.
Vascular endothelial growth factor and placenta growth factor in intrauterine growth-restricted fetuses and neonates.
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DOI：
10.1155/mi.2005.293
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发表时间：
2005-10-24
影响因子：
4.6
通讯作者：
Creatsas G
中科院分区：
文献类型：
--
作者：
Malamitsi-Puchner A;Boutsikou T;Economou E;Sarandakou A;Makrakis E;Hassiakos D;Creatsas G
血管生成因子血管内皮生长因子（VEGF）和胎盘生长因子（PlGF）分别被缺氧上调和下调。我们的目的是研究上述因素在宫内生长受限（IUGR）的循环水平，并将其水平与婴儿的定制百分位数相关。该研究包括25名IUGR和25名适合胎龄（阿加）的足月单胎婴儿及其母亲。检查母体（MS）、胎儿（UC）和新生儿第1天（N1）和第4天（N4）的血液。MS和N1 PlGF以及UC VEGF水平与婴儿的定制百分位数相关（分别为r = 0.39，P = 0.007，r = 0.34，P = 0.01和r =-0.41，P = 0.004）。此外，UC、N1和N4 VEGF水平在女孩中较高（分别为r = 0.36，P = 0.01，r = 0.33，P = 0.02和r = 0.41，P = 0.005）。总之，正相关和负相关的检查因素与定制的百分位数的婴儿可以依赖于胎盘功能和宫内氧浓度，这两个通常是较低的IUGR的情况下，而较高的VEGF水平的女孩应该可能归因于雌激素的刺激作用。
The angiogenic factors vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) are respectively up- and downregulated by hypoxia. We aimed to study circulating levels of the above factors in intrauterine growth restriction (IUGR) and to correlate their levels with the customized centiles of the infants. The study included 25 IUGR and 25 appropriate for gestational age (AGA) full-term, singleton infants and their mothers. Maternal (MS), fetal (UC), and neonatal day 1 (N1) and 4 (N4) blood was examined. MS and N1 PlGF, as well as UC VEGF levels correlated with the customized centiles of the infants (r = 0.39, P = .007, r = 0.34, P = .01, and r = −0.41, P = .004, resp). Furthermore, UC, N1, and N4 VEGF levels were higher in girls (r = 0.36, P = .01, r = 0.33, P = .02, and r = 0.41, P = .005 resp). In conclusion, positive and negative correlations of examined factors with the customized centiles of the infant could rely on placental function and intrauterine oxygen concentrations—both being usually lower in IUGR cases—while higher VEGF levels in girls should possibly be attributed to the stimulating action of estrogens.