SIMULTANEOUS IMMUNOLOGICAL STUDIES OF SKIN AND KIDNEY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICOPATHOLOGIC CORRELATIONS
SIMULTANEOUS IMMUNOLOGICAL STUDIES OF SKIN AND KIDNEY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICOPATHOLOGIC CORRELATIONS
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DOI：
10.1002/art.1780220809
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
KOHLER, PF
中科院分区：
文献类型：
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作者：
MORRIS, RJ;GUGGENHEIM, SJ;KOHLER, PF
对系统性红斑狼疮 (SLE) 患者同时进行肾脏和正常皮肤的活检 (32)，以确定皮肤中免疫反应物的沉积是否与肾损伤的严重程度或与全身性疾病活动的几种血清学测量相关。真皮-表皮交界处的免疫荧光沉积物（狼疮带试验）与肾小球肾炎的任何临床或组织学测量或血清学异常无关。 56% 的皮肤活检中发现真皮小静脉中的免疫沉积物，其与低补体血症和血清中免疫复合物水平较高有关，并可能与肾小球内皮下电子致密沉积物有关。硫唑嘌呤治疗与表皮下和血管免疫沉积物的缺失相关。 13 名患者的连续皮肤活检的免疫荧光结果高度不一致。狼疮带测试在临床上仅用作诊断辅助，但对于评估狼疮的肾脏或血清学活动没有帮助。免疫球蛋白或补体的真皮血管沉积比以前认识到的更频繁，并且与循环免疫复合物的测量相关。
Biopsies (32) of kidneys and normal skin were performed simultaneously on patients with systemic lupus erythematosus (SLE) to determine whether the deposition of immune reactants in skin was correlated with the severity of renal injury or with several serologic measures of systemic disease activity. Immunofluorescent deposits at the dermal-epidermal junction (lupus band test) did not correlate with any clinical or histologic measures of glomerulonephritis or with serologic abnormalities. Immune deposits in dermal venules were found in 56% of the skin biopsies and were correlated with hypocomplementemia and higher levels of immune complexes in serum and possibly with glomerular subendothelial electron dense deposits. Azathioprine therapy was correlated with absence of subepidermal and vascular immune deposits. Immunofluorescent findings on serial skin biopsies on 13 patients were highly inconsistent. The lupus band test is clinically useful only as diagnostic aid but not helpful in assessing renal or serologic activity of lupus. Dermal vascular deposits of immunoglobulin or complement are more frequent than previously recognized and correlate with measures of circulating immune complexes.