Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children
Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children
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DOI：
10.1128/aac.44.1.43-50.2000
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发表时间：
2000-01-01
影响因子：
4.9
通讯作者：
Yagupsky, P
中科院分区：
文献类型：
--
作者：
Dagan, R;Leibovitz, E;Yagupsky, P
本研究采用前瞻性、开放性、随机对照的方法，观察头孢克洛与阿奇霉素治疗急性中耳炎（AOM）的细菌学疗效。在入组研究时和开始治疗后3 - 4天进行鼓室穿刺术。两种药物治疗3 - 4天后，细菌学失败发生在培养阳性患者中的比例很高，特别是那些由流感嗜血杆菌引起的AOM患者（阿奇霉素治疗组33例中有16例[53%]，头孢克洛治疗组34例中有13例[52%]）。虽然可以证明肺炎链球菌的病原体持续存在与相应药物MIC增加的明确相关性，但在E-I中未发现此类相关性。流感。提出了H.流感嗜血杆菌引起的AOM，应大大低于目前的头孢克洛和阿奇霉素。流感。
A prospective, open-label, randomized study was conducted in order to determine the bacteriologic efficacies of cefaclor and azithromycin in acute otitis media (AOM). Tympanocentesis was performed on entry into the study and 3 to 4 days after initiation of treatment. Bacteriologic failure after 3 to 4 days of treatment with both drugs occurred in a high proportion of culture-positive patients, especially in those in whom AOM was caused by Haemophilus influenzae (16 of 33 [53%] of those treated with azithromycin and 13 of 34 [52%] of those treated with cefaclor). Although a clear correlation of the persistence of the pathogen with increased MICs of the respective drugs could be demonstrated for Streptococcus pneumoniae, no such correlation was found for E-I. influenzae. It is proposed that susceptibility breakpoints for H. influenzae should be considerably lower than the current ones for both cefaclor and azithromycin for AOM caused by H. influenzae.