Can Inflammatory and Nutritional Serum Markers Predict Chemotherapy Outcomes and Survival in Advanced Stage Nonsmall Cell Lung Cancer Patients?
Can Inflammatory and Nutritional Serum Markers Predict Chemotherapy Outcomes and Survival in Advanced Stage Nonsmall Cell Lung Cancer Patients?
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DOI：
10.1155/2019/1648072
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Oztop, Ilhan
中科院分区：
文献类型：
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作者：
Cehreli, Ruksan;Yavuzsen, Tugba;Oztop, Ilhan
目的.探讨营养和炎症指标对晚期非小细胞肺癌（NSCLC）患者化疗疗效和生存率的预测价值，以及对继发性营养不良和恶病质的预测价值。方法.前瞻性研究登记了25例诊断为aNSCLC的患者。营养不良通过主观全面评估（SGA）确定，体能状态通过东部肿瘤协作组（ECOG）标准确定。治疗前记录血清白蛋白、前白蛋白、维生素D、锌（Zn）、C反应蛋白（CRP）、白细胞介素6（IL-6）、白细胞介素1（IL-1）、肿瘤坏死因子-α（TNF-α）、脂蛋白脂酶（LPL）水平及格拉斯哥预后评分（GPS）。前瞻性随访患者的治疗结果和生存率。结果由于在4个月随访期间有18名患者死亡，因此无法对炎症和营养标志物进行充分测量。然而，7例患者完成了治疗期，可以在三个阶段进行这些标志物的评价。84%的患者为男性，平均年龄为63.3 ± 8.7岁。营养不良的SGA评估显示5例（20%）患者营养良好（A），12例（48%）中度营养不良（B），8例（32%）重度营养不良（C）。低水平的血清白蛋白（
Purpose. To determine the values of prognostic nutritional and inflammatory markers in chemotherapy outcomes and survival in the patients with advanced nonsmall cell lung cancer (NSCLC) and also in the secondary malnutrition and cachexia. Methods. Twenty-five patients with diagnosis of aNSCLC were registered for the prospective study. Malnutrition was determined by the Subjective Global Assessment (SGA) and performance status by criteria of the Eastern Cooperative Oncology Group (ECOG). Before treatment, serum levels of albumin, prealbumin, vitamin D, zinc (Zn), C-reactive protein (CRP), IL-6, IL-1 , TNF-, lipoprotein lipase (LPL), and the Glasgow Prognostic Score (GPS) were recorded. Patients were followed prospectively for treatment outcomes and survival. Results. Due to the deaths of 18 patients during the 4-month follow-up period, no adequate measurements of inflammatory and nutritional markers could be performed. However, seven patients completed the treatment period and evaluations of these markers could be performed during the three periods. Eighty-four percent of patients were male with a mean age of 63.3 +/- 8.7 years. Evaluation of the malnutrition by SGA showed that 5 (20%) patients were well nourished (A), 12(48%) were moderately malnourished (B), and 8(32%) were severely malnourished (C). Low levels of serum albumin (