Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia
Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia
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DOI：
10.1007/s10552-007-0119-x
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发表时间：
2007-05-01
影响因子：
2.3
通讯作者：
Smith, Joseph A., Jr.
中科院分区：
文献类型：
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作者：
Fowke, Jay H.;Motley, Saundra S.;Smith, Joseph A., Jr.
肥胖与前列腺癌之间的关系仍不清楚。我们研究了前列腺体积对肥胖和前列腺癌关联的影响。通过多中心、快速招募方案，在诊断前收集体重和体型测量数据，并审查医学图表的病理结果（n = 420 名对照、119 名高级前列腺上皮内瘤变 (PIN) 病例和 286 名癌症病例 (41% Gleason > 6)。在调整年龄、PSA 水平和病史、DRE 结果以及活检时的核心数量的多变量逻辑回归模型中，BMI 与 BMI 之间的关联癌症仅限于前列腺体积较小的男性（体积 < 40 cm(3)：ORBMI >= 30 = 2.17 (1.09, 4.32)，p(趋势) = 0.02；体积 >= 40 cm(3)：ORBMI >= 30 = 0.77 (0.34, 1.77)，p(趋势) = 0.17；p（交互作用）=同样，WHR 和 PIN 的相关性因前列腺体积而显着改变（体积 < 40 cm(3)：OR(WHR：Tertile 3 与 T1) = 3.76 (1.54, 9.21) (p(趋势) < 0.01)；体积 >= 40 m(3)：OR(WHR：T3 与 T1) = 0.63 (0.32， 1.23) (p(趋势) = 0.17)；p(交互作用) < 0.01) 总之，在没有肥胖相关前列腺肿大引起的活检取样误差的情况下，前列腺体积起到调节作用，BMI 和 WHR 分别与前列腺癌或 PIN 显着相关。
The relationship between obesity and prostate cancer remains unclear. We investigated the effect of prostate volume on the obesity and prostate cancer association. With a multi-centered, rapid-recruitment protocol, weight and body size measurements were collected prior to diagnosis, and medical charts were reviewed for pathology results (n = 420 controls, 119 high-grade prostatic intraepithelial neoplasia (PIN) cases, and 286 cancer cases (41% Gleason > 6). In multivariable logistic regression models adjusting for age, PSA levels and history, DRE results, and number of cores at biopsy, the association between BMI and cancer was restricted to men with a smaller prostate volume (volume < 40 cm(3): ORBMI >= 30 = 2.17 (1.09, 4.32), p(trend) = 0.02; volume >= 40 cm(3): ORBMI >= 30 = 0.77 (0.34, 1.77), p(trend) = 0.17; p (interaction) = 0.03). Similarly, the WHR and PIN association was significantly modified by prostate volume (volume < 40 cm(3): OR(WHR: Tertile 3 vs. T1) = 3.76 (1.54, 9.21) (p(trend) < 0.01); volume >= 40 m(3): OR(WHR: T3 vs. T1) = 0.63 (0.32, 1.23) (p(trend) = 0.17); p(interaction) < 0.01). In conclusion, prostate volume acts as a modifier, and BMI and WHR are significantly associated with prostate cancer or PIN, respectively, in the absence of biopsy sampling error derived from obesity-related prostate enlargement.