Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development
Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development
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DOI：
10.1016/s0925-4773(01)00457-9
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发表时间：
2001-09-01
影响因子：
2.6
通讯作者：
Jiang, RL
中科院分区：
文献类型：
--
作者：
Lan, Y;Kingsley, PD;Jiang, RL
我们分离出了一个新的小鼠基因，即odd - skipped相关基因2（Osr2），它编码一种含锌指结构的蛋白质，与果蝇的Odd - skipped相关。推测的OSR2蛋白与先前报道的Osr1基因产物总体上有65%的氨基酸序列同一性，在锌指区域有98%的序列同一性。在小鼠胚胎发育过程中，Osr2的表达在胚胎第9.25天首次被检测到，特异性地出现在中肾小泡中。到胚胎第10.0天，在紧邻上颌突的下颌喙侧间充质中也观察到Osr2的表达。在发育的肢芽中，Osr2在一个独特的间充质区域表达，并且Osr2表达的起始遵循从前肢到后肢的独特的背腹发育时间顺序。在颅面发育过程中，Osr2在下颌突、上颌突以及发育中的腭中呈现动态表达模式。在牙齿和肾脏发育过程中，Osr2也在上皮 - 间充质相互作用的部位表达。（C）2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
We have isolated a new mouse gene, odd-skipped related 2 (Osr2), that encodes a zinc finger containing protein related to Drosophila Odd-skipped. The putative OSR2 protein shares 65% amino acid sequence identity overall and 98% sequence identity in the zinc finger region. respectively, with the previously reported Osr1 gene product. During mouse embryonic development, Osr2 expression is first detected at E9.25, specifically in the mesonephric vesicles. By E10.0, Osr2 expression is also observed in the rostro-lateral mandibular mesenchyme immediately adjacent to the maxillary processes. In the developing limb buds, Osr2 is expressed in a unique mesenchymal domain and the onset of Osr2 expression follows a distinct dorsal to ventral developmental time sequence beginning in the forelimb and then in the hindlimb. Osr2 exhibits a dynamic expression pattern during craniofacial development, in the mandibular and maxillary processes as well as the developing palate. Osr2 is also expressed at sites of epithelial-mesenchymal interactions during tooth and kidney development. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.