The genetic basis of adaptive pigmentation variation in Drosophila melanogaster
The genetic basis of adaptive pigmentation variation in Drosophila melanogaster
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DOI：
10.1111/j.1365-294x.2007.03324.x
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发表时间：
2007-07-01
影响因子：
4.9
通讯作者：
Aquadro, Charles F.
中科院分区：
文献类型：
--
作者：
Pool, John E.;Aquadro, Charles F.
在对黑腹果蝇种群样本的广泛调查中，发现腹部色素沉着的水平高度可变，并且在地理上存在差异。深色色素沉着和高海拔之间存在很强的正相关性，表明对特定环境的适应。在候选基因乌木的DNA序列多态性揭示了一个明确的关联与纯合子第三染色体系的色素沉着。测序的最暗的线具有几乎相同的单倍型，跨越乌木的蛋白质编码外显子上游14.5 kb。因此，自然选择可能通过影响乌木的调节而提高了赋予腹部深色色素沉着的等位基因的频率。
In a broad survey of Drosophila melanogaster population samples, levels of abdominal pigmentation were found to be highly variable and geographically differentiated. A strong positive correlation was found between dark pigmentation and high altitude, suggesting adaptation to specific environments. DNA sequence polymorphism at the candidate gene ebony revealed a clear association with the pigmentation of homozygous third chromosome lines. The darkest lines sequenced had nearly identical haplotypes spanning 14.5 kb upstream of the protein-coding exons of ebony. Thus, natural selection may have elevated the frequency of an allele that confers dark abdominal pigmentation by influencing the regulation of ebony.