Comparison of clinical severity and epidemiological spectrum between coronavirus disease 2019 and influenza in children.
Comparison of clinical severity and epidemiological spectrum between coronavirus disease 2019 and influenza in children.
复制标题
DOI：
10.1038/s41598-021-85340-0
复制
发表时间：
2021-03-11
影响因子：
4.6
通讯作者：
Marczyńska M
中科院分区：
文献类型：
--
作者：
Pokorska-Śpiewak M;Talarek E;Popielska J;Nowicka K;Ołdakowska A;Zawadka K;Kowalik-Mikołajewska B;Tomasik A;Dobrzeniecka A;Lipińska M;Krynicka-Czech B;Coupland U;Stańska-Perka A;Ludek M;Marczyńska M
关于2019年新型冠状病毒病（COVID-19）儿童的数据有限，来自欧洲的研究也很少。我们分析了2020年2月1日至4月15日期间疑似COVID-19的0-18岁儿童的临床严重程度和流行病学方面。鼻咽拭子的RT-PCR用于确认COVID-19。319名儿童符合疑似病例标准。15/319（4.7%）例患者（8例男性;平均年龄10.5岁）被诊断为COVID-19。所有人都与受感染的亲属有过家庭接触。5例（33.3%）患者无症状。9/15例（60.0%）患儿的病程为轻度，1/15例（6.7%）为中度，症状如下：发热（46.7%）、咳嗽（40%）、腹泻（20%）、呕吐（13.3%）、鼻炎（6.7%）和呼吸急促（6.7%）。在COVID-19阴性患者中，确诊了其他感染，包括32/319（10%）的流感。根据临床表现，COVID-19和流感的临床病程存在显著差异。总之，COVID-19在儿童中的临床病程通常是轻度或无症状的。在怀疑患有COVID-19的儿童中，其他感染也不应被忽视。儿童感染COVID-19的主要风险因素是与受感染亲属的家庭接触。
Data on the novel coronavirus disease 2019 (COVID-19) in children are limited, and studies from Europe are scarce. We analyzed the clinical severity and epidemiologic aspects of COVID-19 in consecutive children aged 0–18 years, referred with a suspicion of COVID-19 between February 1, and April 15, 2020. RT-PCR on a nasopharyngeal swab was used to confirm COVID-19. 319 children met the criteria of a suspected case. COVID-19 was diagnosed in 15/319 (4.7%) patients (8 male; mean age 10.5 years). All of them had household contact with an infected relative. Five (33.3%) patients were asymptomatic. In 9/15 (60.0%) children, the course of the disease was mild, and in 1/15 (6.7%), it was moderate, with the following symptoms: fever (46.7%), cough (40%), diarrhea (20%), vomiting (13.3%), rhinitis (6.7%), and shortness of breath (6.7%). In the COVID-19-negative patients, other infections were confirmed, including influenza in 32/319 (10%). The clinical course of COVID-19 and influenza differed significantly based on the clinical presentation. In conclusion, the clinical course of COVID-19 in children is usually mild or asymptomatic. In children suspected of having COVID-19, other infections should not be overlooked. The main risk factor for COVID-19 in children is household contact with an infected relative.
登录
查看更多内容
影响因子：
56.3
作者：
Qiu, Haiyan;Wu, Junhua;Chen, Dong
通讯作者：
Chen, Dong
影响因子：
3.6
作者：
Dong, Yi;Wang, Jian;Zhao, Pan
通讯作者：
Zhao, Pan
DOI：
10.15585/mmwr.mm6915e4
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team
影响因子：
158.5
作者：
Guan, W.;Ni, Z.;Zhong, N.
通讯作者：
Zhong, N.
影响因子：
3.6
作者：
Zimmermann, Petra;Curtis, Nigel
通讯作者：
Curtis, Nigel